The Effect of Pregabalin on Postoperative Pain in Patients Undergoing Abdominal Surgery under General Anesthesia | ||||
| The Medical Journal of Cairo University | ||||
| Volume 91, Issue 06, June 2023, Page 567-575 PDF (238.91 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2023.318266 | ||||
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| Author | ||||
| AHMED F. KORAITIM, M.D. AHMED M.A.I. GAMAL ELDIN, M.Sc.; AMR E. ABD ELHAMID, M.D.; HANAA A. EL GENDY, M.D. | ||||
| The Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine Ain Shams University | ||||
| Abstract | ||||
| Abstract Background: Acute postoperative pain and side effects can be serious problems, due to either insufficient or excessive treatment. If analgesic treatment is begun after a painful stimulus, treating postoperative pain can be challenging because of the possibility of peripheral hypersensitivity and central nervous system hyperexcitability. Pre-emptive analgesia focuses on reducing postoperative opioid consumption and pain levels, decreasing the incidence of adverse events and improving patient satisfaction. Several pre-emptive analgesic regimens have been tried in the perioperative period, including opioids, nonsteroidal anti-inflammatory drugs, and so on. Aim of Study: To evaluate the effects of oral pregabalin, before abdominal surgery, on postoperative pain intensity and analgesic requirements (primary outcome), and the incidence of post-operative nausea and vomiting (secondary outcome). Patients and Methods: This randomized controlled trial was conducted on 60 adult healthy patients aged 21-50 years of both sex, ASA physical status I and II undergoing elective abdominal surgery (open or laparoscopic). Patients were equally randomized to: Group A: Received pregabalin 300mg/12hrs 24 hrs before surgery. Group B: Did not receive pregabalin. Results: Time of first analgesic requirement was signifi-cantly delayed in group A compared to group B (p-value <0.001). Total pethidine consumption was significantly lower in group A compared to group B (p-value <0.001). Incidence of PONV was 5 (16.67%) patients in group A and 13 (43.33%) in group B. Incidence of dizziness was 20 (66.67%) patients in group A and 4 (13.33%) in group B. Incidence of PONV was significantly lower in group A compared to group B (p -value=0.024). Incidence of dizziness was significantly higher in group A compared to group B (p-value <0.001). Respiratory depression and hypotension were insignificantly different between both groups. Conclusion: Preoperative administration of 300mg/12hrs 24hrs of pregabalin resulted in a significant reduction pain score, intraoperative fentanyl consumption, total pethidine consumption and incidence of PONV following elective abdominal surgery but with higher incidence of dizziness. | ||||
| Keywords | ||||
| General anesthesia; Pregabalin | ||||
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