Drug residue profiles of Cefquinome in the mullet (Mugil cephalus) in saltwater at 24 °C. | ||||
| Egyptian Journal of Aquatic Biology and Fisheries | ||||
| Article 21, Volume 27, Issue 5, September and October 2023, Page 321-331 PDF (692.22 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejabf.2023.318501 | ||||
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| Author | ||||
| Nesma E. Eleissawy et al. | ||||
| Abstract | ||||
| The present study was performed to estimate the residue concentration of cefquinome in mullets using High-performance thin-layer chromatography (HPTLC). A total of 40 apparently healthy mullets (Mugil cephalus) weighing 750±50g were transported alive to 8 glass aquaria. Cefquinone sulfate (Cobactan® 2.5%) was given as a single intramuscular dose of 10 mg/kg body weight. At each sampling point (6, 24, 48-, 72-, 96- and 120 hrs post-medication), serum, muscle, liver, and kidney samples were collected to investigate cefquinome residual concentrations using the HPTLC technique. The maximum concentrations were recorded in the following order: liver > kidney > serum > muscle. Cefquinome concentration in muscles decreased gradually to become under the detection limit (35ng/mL) at 4 days (96 hrs) post-medication. At this time, cefquinome concentrations were still detectable in both the liver and kidney and up to the end of the 5th-day post-medication. Furthermore, the cefquinome withdrawal times were calculated to be 61.7, 105.6, and 90.5 hrs in Mugil’s muscles, liver, and kidney respectively. Hence, cefquinome withdrawal time was estimated to be 3 days in mullet’s muscles after a single intramuscular dose of 10 mg/kg body weight under 24 C water temperature. If cefquinome will be used therapeutically in broader mullet, 2-3 intramuscular doses of 10 mg/Kg b.wt. with 2.5-day intervals should ensure a sufficient MIC for most of the bacterial pathogens. | ||||
| Keywords | ||||
| Cefquinome; Food Safety; HPTLC; Mugil cephalus; Residues | ||||
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