Serum High Mobility Group Box 1 Protein as an Early Marker of Pulmonary Arterial Hypertension in Neonates
Hasan, B., Ahmed, H., Ahmed, I., El Gebaly, S. (2023). Serum High Mobility Group Box 1 Protein as an Early Marker of Pulmonary Arterial Hypertension in Neonates. EKB Journal Management System, (), -. doi: 10.21608/zumj.2023.236511.2895
Beshir Abdallah Hasan; Hanan Samir Ahmed; Israa Beshir Ahmed; Sherief Mohammed El Gebaly. "Serum High Mobility Group Box 1 Protein as an Early Marker of Pulmonary Arterial Hypertension in Neonates". EKB Journal Management System, , , 2023, -. doi: 10.21608/zumj.2023.236511.2895
Hasan, B., Ahmed, H., Ahmed, I., El Gebaly, S. (2023). 'Serum High Mobility Group Box 1 Protein as an Early Marker of Pulmonary Arterial Hypertension in Neonates', EKB Journal Management System, (), pp. -. doi: 10.21608/zumj.2023.236511.2895
Hasan, B., Ahmed, H., Ahmed, I., El Gebaly, S. Serum High Mobility Group Box 1 Protein as an Early Marker of Pulmonary Arterial Hypertension in Neonates. EKB Journal Management System, 2023; (): -. doi: 10.21608/zumj.2023.236511.2895

Serum High Mobility Group Box 1 Protein as an Early Marker of Pulmonary Arterial Hypertension in Neonates

Zagazig University Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 24 September 2023  XML
Document Type: Original Article
DOI: 10.21608/zumj.2023.236511.2895
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Authors
Beshir Abdallah Hasan1; Hanan Samir Ahmed2; Israa Beshir Ahmed email 1; Sherief Mohammed El Gebaly1
1Pediatrics Department, Faculty of medicine, Zagazig university, Egypt
2Clinical Pathology Department, Faculty of medicine Zagazig University, Egypt
Abstract
Background: Inflammation plays an important role in neonatal hypoxia-induced organ damage. Newborns with perinatal asphyxia often develop persistent pulmonary hypertension of the neonate.

Aim: Early detection of pulmonary arterial hypertension in newborn to improve patient morbidity and mortality by estimated serum HMGB1 by ELISA.

Patients and methods: This case control study was conducted in Zagazig University Hospital, Pediatric (NICU) and clinical pathology departments, during a period of eight months from March 2020 to January 2021. Following were the three groups into which patients were split: Group 1: fifteen apparently healthy neonates included 11 male and 4 females, group 2: fifteen congenital heart diseases without pulmonary hypertension neonates included 10 male and 5 female and group 3: Fifteen congenital heart diseases with pulmonary hypertension neonates included 10 male and 5 female.

Results: There is a statistically significant difference between the groups that were looked at for HMGB1 expression. When compared pairwise, CHD with pulmonary hypertension and the other groups show a significant difference (the greatest level was in CHD with pulmonary hypertension) hypertension then CHD without pulmonary hypertension then control group).

Conclusion: HMGB1 levels in newborns with pulmonary hypertension increased.
Keywords
HMGB1; Neonates; pulmonary arterial hypertension
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