Serum High Mobility Group Box 1 Protein as an Early Marker of Pulmonary Arterial Hypertension in Neonates | ||||
| Zagazig University Medical Journal | ||||
| Article 27, Volume 30, Issue 1.4, May and June 2024, Page 294-303 PDF (504.42 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2023.236511.2895 | ||||
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| Authors | ||||
Beshir Abdallah Hasan1; Hanan Samir Ahmed2; Israa Beshir Ahmed  1; Sherief Mohammed El Gebaly1
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| 1Pediatrics Department, Faculty of medicine, Zagazig university, Egypt | ||||
| 2Clinical Pathology Department, Faculty of medicine Zagazig University, Egypt | ||||
| Abstract | ||||
| Background: Inflammation plays an important role in neonatal hypoxia-induced organ damage. Newborns with perinatal asphyxia often develop persistent pulmonary hypertension of the neonate. Aim: Early detection of pulmonary arterial hypertension in newborn to improve patient morbidity and mortality by estimated serum HMGB1 by ELISA. Patients and methods: This case control study was conducted in Zagazig University Hospital, Pediatric (NICU) and clinical pathology departments, during a period of eight months from March 2020 to January 2021. Following were the three groups into which patients were split: Group 1: fifteen apparently healthy neonates included 11 male and 4 females, group 2: fifteen congenital heart diseases without pulmonary hypertension neonates included 10 male and 5 female and group 3: Fifteen congenital heart diseases with pulmonary hypertension neonates included 10 male and 5 female. Results: There is a statistically significant difference between the groups that were looked at for HMGB1 expression. When compared pairwise, CHD with pulmonary hypertension and the other groups show a significant difference (the greatest level was in CHD with pulmonary hypertension) hypertension then CHD without pulmonary hypertension then control group). Conclusion: HMGB1 levels in newborns with pulmonary hypertension increased. | ||||
| Keywords | ||||
| HMGB1; Neonates; pulmonary arterial hypertension | ||||
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