Derivatives contain dimethylaminopyridine as SIRT2 inhibitors: A mini review | ||||
| Journal of advanced Biomedical and Pharmaceutical Sciences | ||||
| Article 2, Volume 6, Issue 4, October 2023, Page 166-173 PDF (1.82 MB) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/jabps.2023.219233.1191 | ||||
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| Authors | ||||
Mostafa Badran1; Samar H Abbas   2; Mikako Fujita3; Mohamed Osman4
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| 1Department of Medicinal Chemistry, Faculty of Pharmacy, South Valley University, Qena, 83523, Egypt | ||||
| 2Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519-Minia, Egypt | ||||
| 3Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto, 862-0973, Japan | ||||
| 4Medicinal Chemistry Department, Faculty of Pharmacy, Minia University. | ||||
| Abstract | ||||
| The development of new compounds inhibiting SIRT2, a protein that regulates various biological processes, has attracted significant attention in recent years. This study reported dimethylaminopyridine (DMAP) synthesis and evaluation as a new scaffold for SIRT2 inhibition. DMAP derivatives were designed and synthesized using a combination of computational modeling and synthetic chemistry approaches. A high-throughput screening assay was used to evaluate the ability of compounds to inhibit SIRT2. The most potent compounds were identified and further characterized using cellular and enzymatic assays. This review suggests that DMAP could be a promising scaffold for developing novel SIRT2 inhibitors with potential anticancer activity. | ||||
| Keywords | ||||
| Dimethyl aminopyridine; HDACs, SiRT2 inhibitors | ||||
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