CLONAZEPAM INDUCED SUB CHRONIC HEPATORENAL TOXICITY IN RATS AND THE PROTECTIVE ROLE OF ALPHA-TOCOPHEROL | ||||
| The Egyptian Journal of Forensic Sciences and Applied Toxicology | ||||
| Volume 23, Issue 3, September 2023, Page 77-95 PDF (2.1 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejfsat.2023.205239.1289 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
nada elsayed Abdel-raof 1; Mahmoud Ahmed Khattab2; Fatma Abdel Wahab Abdel Maksoud3; Maha Emad Eldein4; Ahmed Elshatory5; Walaa Awad6; Mohammad Abd-El-Samee El-Kattan  7
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| 1department of forensic medicine and clinical toxicology cairo university | ||||
| 2Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Cairo, Egypt. | ||||
| 3Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt | ||||
| 4Department of Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt. | ||||
| 5Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Cairo University, Cairo, Egypt. | ||||
| 6Clinical Pharmacy Department, Abo El-Reesh Al Mounira Hospital, Cairo University, Cairo, Egypt | ||||
| 7Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||||
| Abstract | ||||
| Background: Clonazepam (CZP) is an antiepileptic drug approved in 1976 by Food and Drug Administration (FDA) for treatment of various types of seizures, Clonazepam has a high potential for abuse, as well as tolerance, physical dependence, and ultimately addiction. Although many studies confirmed the deleterious effects of other antiepileptic like valproic acid and carbamazepine, those of clonazepam are minimal. Objectives: This research aimed to study and evaluate the hepatotoxic and nephrotoxic effects of sub chronic high dose administration of clonazepam and the protective effect of alpha-tocopherol “vitamin E” (V.E). Methods: Forty (40) healthy male albino rats were included. They were randomly divided into four equal groups (10 rats each): group I (normal saline), group II (CZP misuse), and group III (V.E) and group ΙV (CZP + V.E). All rats received the commenced drugs for 50 days. Serum levels of AST, ALT, ALP, urea, creatinine and uric acid were measured. Liver and kidney tissues were taken for histopathology. Results: clonazepam in high doses increased hepatic and renal biomarkers levels, disrupted hepatic and renal tissues and increased the number of degenerated cells. V.E treatment significantly attenuated the deleterious effects induced by clonazepam. | ||||
| Keywords | ||||
| Keywords: Clonazepam; Misuse; Hepatotoxicity; Nephrotoxicity; alpha-tocopherol; Rats | ||||
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