Hypervirulent klebseilla pneumoniae (hvKp) is a new threat
mohamed, D., Mohamed, M., hassan, N., Badawy, A. (2023). Hypervirulent klebseilla pneumoniae (hvKp) is a new threat. EKB Journal Management System, 27(3.), 21-26. doi: 10.21608/smj.2023.227205.1405
dina hamada mohamed; Mona fattouh Mohamed; Nessma atef hassan; Ashgan Hussein Badawy. "Hypervirulent klebseilla pneumoniae (hvKp) is a new threat". EKB Journal Management System, 27, 3., 2023, 21-26. doi: 10.21608/smj.2023.227205.1405
mohamed, D., Mohamed, M., hassan, N., Badawy, A. (2023). 'Hypervirulent klebseilla pneumoniae (hvKp) is a new threat', EKB Journal Management System, 27(3.), pp. 21-26. doi: 10.21608/smj.2023.227205.1405
mohamed, D., Mohamed, M., hassan, N., Badawy, A. Hypervirulent klebseilla pneumoniae (hvKp) is a new threat. EKB Journal Management System, 2023; 27(3.): 21-26. doi: 10.21608/smj.2023.227205.1405

Hypervirulent klebseilla pneumoniae (hvKp) is a new threat

Sohag Medical Journal
Volume 27, Issue 3., 2023, Page 21-26  XML PDF (875.5 K)
Document Type: Review Article
DOI: 10.21608/smj.2023.227205.1405
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Authors
dina hamada mohamed email 1; Mona fattouh Mohamed2; Nessma atef hassan3; Ashgan Hussein Badawy1
1medical microbiology and immunology
2Department of Medical Microbiology and Immunology, Sohag Faculty of Medicine, Sohag University
3Medical Microbiology and Immunology, Faculty of Medicine, Sohag University, Egypt
Abstract
Hypervirulent K. pneumoniae (hvKp) is a pathogenic strain of K. pneumoniae that is more virulent than classical K. pneumoniae (cKp). hvKp typically infects people in the community who are otherwise healthy. Infections are more common in the Asian Pacific Rim, but they occur worldwide. hvKp infection frequently manifests at various places or metastatically spreads, necessitating source control. hvKp has a greater proclivity to produce central nervous system infection and endophthalmitis, both of which necessitate prompt diagnosis and site-specific treatment.

K. pneumoniae has become a growing global problem in recent decades, owing to its increased resistance and lately concentrated hypervirulence. Despite the fact that SH 1V-1 -lactamase is encoded on the chromosome and is inherent resistance, K. pneumoniae can counteract antimicrobials by a variety of mechanisms, including hydrolyzing enzymes, missing porins, efflux overexpression, topoisomerase, and lipopolysaccharide (LPS) modification (4). Carbapenem-resistant K. pneumoniae (CR-KP) has reached an alarming rate of more than 30.0% among K. pneumoniae strains, posing serious hurdles in clinical practice. The World Health Organization (WHO) published a list of the most "critical" bacteria with an urgent need for novel therapies in 2016, with carbapenem-resistant Enterobacteriaceae (CRE) being designated as a critical priority organism
Keywords
Hypervirulent K. pneumoniae; nosocomial infections; antibiotic resistance
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