Polyvinyl Alcohol/ gelatin/ silver Nanocomposites Treatment for Rats Skin Wound Irradiated by γ-rays
El Khalafawy, G., Elkady, A., El Bedewi, A., Salah, M. (2023). Polyvinyl Alcohol/ gelatin/ silver Nanocomposites Treatment for Rats Skin Wound Irradiated by γ-rays. EKB Journal Management System, 36(1), 11-19. doi: 10.21608/ejrsa.2023.212588.1154
Gh. K. El Khalafawy; A. A. Elkady; A. F. El Bedewi; M. Salah. "Polyvinyl Alcohol/ gelatin/ silver Nanocomposites Treatment for Rats Skin Wound Irradiated by γ-rays". EKB Journal Management System, 36, 1, 2023, 11-19. doi: 10.21608/ejrsa.2023.212588.1154
El Khalafawy, G., Elkady, A., El Bedewi, A., Salah, M. (2023). 'Polyvinyl Alcohol/ gelatin/ silver Nanocomposites Treatment for Rats Skin Wound Irradiated by γ-rays', EKB Journal Management System, 36(1), pp. 11-19. doi: 10.21608/ejrsa.2023.212588.1154
El Khalafawy, G., Elkady, A., El Bedewi, A., Salah, M. Polyvinyl Alcohol/ gelatin/ silver Nanocomposites Treatment for Rats Skin Wound Irradiated by γ-rays. EKB Journal Management System, 2023; 36(1): 11-19. doi: 10.21608/ejrsa.2023.212588.1154

Polyvinyl Alcohol/ gelatin/ silver Nanocomposites Treatment for Rats Skin Wound Irradiated by γ-rays

Egyptian Journal of Radiation Sciences and Applications
Volume 36, Issue 1, 2023, Page 11-19  XML PDF (3.04 MB)
Document Type: Original Article
DOI: 10.21608/ejrsa.2023.212588.1154
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Authors
Gh. K. El Khalafawy1; A. A. Elkady email orcid 1; A. F. El Bedewi1; M. Salah2
1Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt
2Radiation Research of Polymer Chemistry Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority(EAEA), Cairo, Egypt.
Abstract
Cutaneous wound healing is a complex process for the repair of damaged/ injured tissues; it is vital to find an effective method to boost skin healing. The aim of this work was to investigate the role of polyvinyl alcohol (PVA)/ gelatin/ silver nanocomposites, on wound healing. Thirty rats were equally divided into 5 groups as follow: 1) Normal intact skin (NS), 2) Topical garamycin (G), 3) γ-irradiated (8Gy), 4) Poly Vinyl Alcohol (PVA), 5) Poly Vinyl Alcohol+ γ-rays (PVA + γ-rays); rats in groups 2,3,4,5 were subjected to a surgical wound. Rats from each group were sacrificed on the 5th and 21st day from the surgical procedure. Histopathological and biochemical investigations (tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β) and interleukin-8 (IL-8)) were evaluated in the wound region of the skin. Our results revealed that γ-irradiation delayed the healing process of rat’s skin wound with less reepitheliazation, prominent fatty tissues and higher levels of inflammatory markers PVA gelatin/ silver nanocomposites treatment enhanced healing process, as presented by both pathological and biochemical results. In Conclusion: PVA/ gelatin/ silver nanocomposites treatment may enhance skin healing. 
Keywords
PVA; Rats; Skin; Wound; γ-rays
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