Repairing an A unilateral Critical-Sized Mandibular Defect in Rabbits Using Hydroxyapatite Matrix, Polylactic- Polyglycolic Acid (HA/PLGA) Scaffold, and Platelet Rich Plasma[PRP]
Ali, A., Shamaa, A., Sabry, D., mohamed, S. (2023). Repairing an A unilateral Critical-Sized Mandibular Defect in Rabbits Using Hydroxyapatite Matrix, Polylactic- Polyglycolic Acid (HA/PLGA) Scaffold, and Platelet Rich Plasma[PRP]. EKB Journal Management System, 69(4), 2655-2663. doi: 10.21608/edj.2023.217475.2598
Afaf Khalaf Ali; Ali Shamaa; Dina Sabry; Sahar sayed mohamed. "Repairing an A unilateral Critical-Sized Mandibular Defect in Rabbits Using Hydroxyapatite Matrix, Polylactic- Polyglycolic Acid (HA/PLGA) Scaffold, and Platelet Rich Plasma[PRP]". EKB Journal Management System, 69, 4, 2023, 2655-2663. doi: 10.21608/edj.2023.217475.2598
Ali, A., Shamaa, A., Sabry, D., mohamed, S. (2023). 'Repairing an A unilateral Critical-Sized Mandibular Defect in Rabbits Using Hydroxyapatite Matrix, Polylactic- Polyglycolic Acid (HA/PLGA) Scaffold, and Platelet Rich Plasma[PRP]', EKB Journal Management System, 69(4), pp. 2655-2663. doi: 10.21608/edj.2023.217475.2598
Ali, A., Shamaa, A., Sabry, D., mohamed, S. Repairing an A unilateral Critical-Sized Mandibular Defect in Rabbits Using Hydroxyapatite Matrix, Polylactic- Polyglycolic Acid (HA/PLGA) Scaffold, and Platelet Rich Plasma[PRP]. EKB Journal Management System, 2023; 69(4): 2655-2663. doi: 10.21608/edj.2023.217475.2598

Repairing an A unilateral Critical-Sized Mandibular Defect in Rabbits Using Hydroxyapatite Matrix, Polylactic- Polyglycolic Acid (HA/PLGA) Scaffold, and Platelet Rich Plasma[PRP]

Egyptian Dental Journal
Volume 69, Issue 4 - Serial Number 3, October 2023, Page 2655-2663  XML PDF (1.44 MB)
Document Type: Original Article
DOI: 10.21608/edj.2023.217475.2598
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Authors
Afaf Khalaf Ali email orcid 1; Ali Shamaaorcid 2; Dina Sabryorcid 3; Sahar sayed mohamedorcid 4
1Candidate, Oral Biology Department, Faculty of Dentistry, Minia University, Egypt
2Professor, Oral Biology Department, Faculty of Dentistry, Kafr Elsheik University, Minia, Egypt
3Professor of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University
4Assistant Professor, Oral Biology Department, Faculty of Dentistry, Minia University Minia, Egypt
Abstract
Despite extensive research, the use of autologous platelet-rich plasma (PRP) to treat major bone abnormalities remains controversial. As a substitution, allogeneic PRP from donors who have been thoroughly vetted not just produces a more accurate and reliable treatment but also does not require drawing significant amounts of blood. Allogeneic PRP is nevertheless usually understudied, especially given its immunogenicity in this use. This study's objective was to assess the effects of using PLGA/HA scaffold together with platelet-rich plasma (PRP) on bone regeneration of critical-size mandibular defects in a rabbit model. Material and methods: - A total of 18 mandibular defects were made, and three groups (each n = 6) were created. The first group received a hydroxyapatite matrix and polylactic-polyglycolic acid HA/PLGA) scaffold in combination with PRP. The second group received only HA/PLGA scaffolds. The third group, which served as the control, had a critical-sized defect left empty. Specimens were collected and evaluated by means of micro-CT scans and histological analysis after 3 months. Results: PRP + PLGA/HA led to more extensive new bone formation (p < 0.05) in contrast to the PLGA/HA scaffold only group and the control group. In conclusion, In a mandibular rabbit model, a mixture of PRP, PLGA, and HA enhances bone repair. This research supports the use of autologous (PRP) as an over-the-counter treatment for bone repair.
Keywords
platelet-rich plasma (PRP); synthetic scaffolds; bone regeneration; tissue engineering
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