Interleukin-34 level in Gingivitis Patients; Clinical and Biochemical Study

Ahmed, Nada S.; Abuel Ela, hala A.; Fouad, Yasmine A.

doi:10.21608/edj.2023.220511.2622

	Interleukin-34 level in Gingivitis Patients; Clinical and Biochemical Study
Egyptian Dental Journal
Volume 69, Issue 4 - Serial Number 3, October 2023, Page 2705-2711 PDF (391.92 K)
Document Type: Original Article
DOI: 10.21608/edj.2023.220511.2622
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Authors
Nada S. Ahmed ¹; hala A. Abuel Ela ²; Yasmine A. Fouad ³
¹MSc Student
²Professor, Oral Medicine, Periodontology, and Oral Diagnosis, Faculty of Dentistry. Ain Shams University
³Instructor, Oral Medicine, Periodontology, and Oral Diagnosis, Faculty of Dentistry, Ain Shams University
Abstract
Abstract: Objective: The objective of this clinical trial was to compare changes in IL-34 level in Gingival cervicular fluid (GCF) before and after nonsurgical periodontal therapy (NSPT) in individuals with biofilm-induced gingivitis in relation to periodontal clinical signs. Methods and materials: Twenty patients, both genders, aged 20 to 50, have been diagnosed with biofilm-induced gingivitis. The following parameters were considered clinically at baseline and three months after NSPT: probing depth (PD), gingival index (GI), and plaque index (PI). Results: 3 months postoperatively, a substantial reduction in the level of IL-34 in GCF was detected along with better improvement in all clinical parameters compared to preoperative level in addition to positive correlation among changes in the level of GCF IL-34 along with changes in all clinical parameters. Conclusion: IL-34 can be regarded as one of the pro-inflammatory markers of periodontal disease and may be investigated in the future as a potential target for periodontal disease therapy.
Keywords
Keywords: Interleukin-34; biofilm induced gingivitis; non-surgical periodontal therapy; Egypt


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