The Effect of Self Assembling Peptides Versus Sodium Fluoride Varnish on Artificially Induced Enamel Lesions in Human Premolars, In Vitro Study. (Scanning Electron Microscope and Energy Dispersive X-ray Analysis)

Elewa, Shrouk Samy; Elzainy, Medhat Ahmed; Hussein, Safaa Ismail

doi:10.21608/edj.2023.228076.2674

	The Effect of Self Assembling Peptides Versus Sodium Fluoride Varnish on Artificially Induced Enamel Lesions in Human Premolars, In Vitro Study. (Scanning Electron Microscope and Energy Dispersive X-ray Analysis)
Egyptian Dental Journal
Volume 69, Issue 4 - Serial Number 3, October 2023, Page 2793-2805 PDF (2.45 MB)
Document Type: Original Article
DOI: 10.21608/edj.2023.228076.2674
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Authors
Shrouk Samy Elewa ¹; Medhat Ahmed Elzainy ²; Safaa Ismail Hussein ³
¹Demonstrator of Oral Biology, Faculty of Dentistry, Badr University, Cairo, Egypt.
²Professor of Oral Biology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
³Associate professor of Oral Biology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt
Abstract
Abstract Background: Dental caries is a global health concern, with white spot lesions being a critical stage that can be reversed with preventive measures. Topical fluoride is commonly used, but researchers are exploring bioactive materials like self-assembling peptide P11-4 for biomimetic enamel remineralization. Aim: Assessment of biomimetic self assembling peptides P11-4 effect versus sodium fluoride varnish on enamel remineralization. Materials and methods: Thirty-five lower first premolars were alienated for five groups of seven speciemens each. Group I (control): no treatent was applied. The remaining samples were exposed to demineralization. After initiation of lesions, samples were subdivided into four equal groups: Group II: examined immediately. Group III: No treatment was applied. GroupIV: (fluoride group). GroupV: (Curodont Group). Specimens were preserved in artificial saliva. Examination was done after one month using SEM, EDXA and polarized light microscope. Results: EDXA results of Calcium values showed control and Curodont groups had significantly higher values than artificial saliva and demineralized groups. The phosphorous values showed control, artificial saliva, fluoride and Curodont groups had significantly higher values when compared to demineralized group. The Calcium/Phosphorous ratio showed Curodont to have significantly higher value than demineralized and artificial saliva groups. Polarized light microscope results confirmed the SEM-EDXA findings. Conclusion: Self assembling peptide P11-4 was able to remineralize enamel carious lesions more efficiently than sodium fluoride varnish. Key words: Self assembling peptides; Fluoride varnish; Remineralization; SEM; EDXA.
Keywords
Self assembling peptides; Fluoride varnish; Remineralization; SEM; EDXA


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