Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study
Hashem, M., Abdel-Haleem, H., khairy, M., Nassef, A., Essam Eldin, M., D. El Desouky, E. (2023). Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study. EKB Journal Management System, 4(4), 1133-1141. doi: 10.21608/mid.2023.236668.1617
Mohamed B. Hashem; Hanan Abdel-Haleem; Marwa khairy; Ayatallah Amir Nassef; Mahmoud Essam Eldin; Eman D. El Desouky. "Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study". EKB Journal Management System, 4, 4, 2023, 1133-1141. doi: 10.21608/mid.2023.236668.1617
Hashem, M., Abdel-Haleem, H., khairy, M., Nassef, A., Essam Eldin, M., D. El Desouky, E. (2023). 'Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study', EKB Journal Management System, 4(4), pp. 1133-1141. doi: 10.21608/mid.2023.236668.1617
Hashem, M., Abdel-Haleem, H., khairy, M., Nassef, A., Essam Eldin, M., D. El Desouky, E. Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study. EKB Journal Management System, 2023; 4(4): 1133-1141. doi: 10.21608/mid.2023.236668.1617

Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study

Microbes and Infectious Diseases
Article 9, Volume 4, Issue 4, November 2023, Page 1133-1141  XML PDF (573.06 K)
Document Type: Original Article
DOI: 10.21608/mid.2023.236668.1617
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Authors
Mohamed B. Hashem email 1; Hanan Abdel-Haleem1; Marwa khairy1; Ayatallah Amir Nassef2; Mahmoud Essam Eldin1; Eman D. El Desouky3
1Endemic Medicine and Hepatology Unit, Faculty of Medicine, Cairo University, Egypt
2Clinical Pathology Department, Faculty of Medicine, Cairo University, Egypt
3Epidemiology and Biostatistics, National Cancer Institute, Cairo University, Egypt
Abstract
Background:  Hepatitis B virus (HBV) vaccination is mandatory among health care workers due to high risk of exposure to infection. However, the long-term protective effect of HBV vaccine and assessment of HBV vaccination status by measuring HBsAb remain questionable. Aim: assess the protective levels of anti-HBsAb among previously vaccinated medical residents and its relation to duration and doses of vaccine.  Methods: Cross section study conducted on 202 residents working in Kasr Al-Aini Medical hospital (single center) HBV vaccinated. Serum HBsAb titer was tested using Elecsys® Anti-HBs II reagent by automated COBAS device system e-601. The residents were classified according to their protective antibody titer into three groups; negative protective titer (< 10IU/L), positive low protective titer (10-100 IU/L) and high positive protective titer (> 100 IU/L) groups. Results: Only 9.4% had negative protective titer, 35.15% had positive low protective titer and 55.45% had positive high protective titer. Negative protective HBsAb titer was significantly higher in males (15.5%), smokers (26.5%), with incomplete vaccination schedule (26.6%), compulsory vaccinated (53%) and last vaccine dose >10years (60.7%). Multivariate logistic regression analysis revealed that the duration since last vaccination dose (<10years) and completion of vaccination schedule (≥3doses) are the significant independent factors for HBsAb protective levels with p value <0.001 and 0.012. Conclusions: Protective anti-HBsAb level is related to the number of years elapsed since vaccination and the number of vaccine doses.
Keywords
HBV; HBsAb titer; Vaccine; Protective titer
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