Thyroid Disorders in Juvenile Idiopathic Arthritis Patients and Its Correlation with Disease Activity: A Cross-Sectional Study | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 16, Volume 93, Issue 1, October 2023, Page 7002-7008 PDF (578.37 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2023.320239 | ||||
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| Abstract | ||||
| Background: The association between juvenile idiopathic arthritis (JIA) and thyroid disorders has been defined in adults and, less frequently, in children. Objective: The study's goal was to assess thyroid function and the prevalence of thyroid antibodies in patients with juvenile idiopathic arthritis, as well as their relationship to disease activity. Methods: This cross-sectional study included 50 children and adolescents with juvenile idiopathic arthritis. All patients underwent thyroid function tests (thyroid stimulating hormone, free thyroxine, and free triiodothyronine), anti-thyroglobulin and anti-peroxidase antibodies by enzyme-linked immunosorbent assays. Results: The study showed that 52% of the patients were males and 48% were females. Their median age value was 9 years old. Thyroid abnormalities were detected in 52% of JIA patients. Overt hypothyroidism was the most prevalent disorder [14 patients (28%)], followed by subclinical hypothyroidism [11 patients (22%)], and then subclinical hyperthyroidism [1 patient (2%)], while 24 patients (48%) were euthyroid. Thyroid antibodies showed a normal level in all patients. On comparing thyroid function tests among patients with active and inactive JIA, no statistically significant difference was observed in thyroid hormone levels. Conclusion: To reduce the risk of delayed or undiagnosed thyroid diseases, it is necessary to routinely screen for thyroid function abnormalities in children with juvenile idiopathic arthritis. | ||||
| Keywords | ||||
| Juvenile idiopathic arthritis; Thyroid autoantibodies; Thyroid function; Hypothyroidism | ||||
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