Eco-friendly and Regiospecific synthesis of Novel (5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide Derivatives

Amer, Amer A.; Ahmed, Doaa H.; Moustafa, Amr H.

doi:10.21608/sjsci.2023.232963.1120

	Eco-friendly and Regiospecific synthesis of Novel (5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide Derivatives
Sohag Journal of Sciences
Volume 9, Issue 1, March 2024, Page 64-68 PDF (326.62 K)
Document Type: Regular Articles
DOI: 10.21608/sjsci.2023.232963.1120
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Authors
Amer A. Amer ¹; Doaa H. Ahmed¹; Amr H. Moustafa¹^{, 2}
¹Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt.
²Faculty of Science, King Salman International University, Ras Sudr, Sinai 46612, Egypt.
Abstract
The Ultrasonic (US) technique is used in the present work as an eco-friendly method for the synthesis of (5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide derivatives. A simple and efficient method has been described for the alkylation of (5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide (1). Besides the IR and NMR spectra, the regioselectivity of the N-alkylation is chemically achieved. Furthermore, fusion of sodium salt of 1 with ethyl bromide in DMF as solvent using ultrasound irradiation as a source of power afforded (1,3-diethyl-5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide (9).
Keywords
Ultrasonic technique; Eco-friendly; Cyanoguanidinophenytoin; Regioselectivity; Alkylation
Supplementary Files SJSCI-2308-1120_Supporting Information.docx

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