Interleukin 8 in Children with Obstructive Sleep Apnea before and after Adenotonsillectomy | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 24, Volume 93, Issue 1, October 2023, Page 7060-7065 PDF (696.31 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2023.320557 | ||||
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| Abstract | ||||
| Background: A reduction in blood oxygen levels and periodic interruptions in breathing during sleep are hallmarks of obstructive sleep apnea (OSA). Objectives: to determine the amount of serum IL-8 in children diagnosed with OSA both before & after undergoing adenotonsillectomy. Patients and methods: Prospective randomized single-arm interventional trial. The research was conducted in the ENT Department of Suez Canal University Hospital, Ismailia City, Egypt. Children experiencing OSA and chronic intermittent hypoxia (CIH) signs during sleep. T & A was done on children as a matter of choice. Children's ages varied from three to twelve years old. Results: We found that there was significant variation among preoperative & postoperative IL-8. There was no significant distinction among preoperative & postoperative O2 levels (p = 0.069), with the mean preoperative O2 level being 98.27% and the mean postoperative O2 level being 98.77%. The preoperative oxygen desaturation index (ODI) was significantly distinct from the postoperative ODI. The preoperative ODI had a mean value of 7.77, whereas the postoperative ODI had a mean value of 2.90. Conclusion: The levels of IL-8 in the children who had OSA were elevated. Children who had OSA showed a significant reduction in their IL-8 levels following adenotonsillectomy. | ||||
| Keywords | ||||
| IL-8; Adenotonsillectomy; Obstructive sleep apnea | ||||
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