Ameliorative potential of sitagliptin and/or calcipotriol on lipopolysaccharide-induced Alzheimer's disease
Kabel, A., borg, H., Abd Elmaaboud, M., Ashour, A. (2019). Ameliorative potential of sitagliptin and/or calcipotriol on lipopolysaccharide-induced Alzheimer's disease. EKB Journal Management System, 39(2), 191-203. doi: 10.21608/besps.2019.11331.1018
Ahmed Kabel; hany mohammad borg; Maaly Abd Elmaaboud; Ahmed Ashour. "Ameliorative potential of sitagliptin and/or calcipotriol on lipopolysaccharide-induced Alzheimer's disease". EKB Journal Management System, 39, 2, 2019, 191-203. doi: 10.21608/besps.2019.11331.1018
Kabel, A., borg, H., Abd Elmaaboud, M., Ashour, A. (2019). 'Ameliorative potential of sitagliptin and/or calcipotriol on lipopolysaccharide-induced Alzheimer's disease', EKB Journal Management System, 39(2), pp. 191-203. doi: 10.21608/besps.2019.11331.1018
Kabel, A., borg, H., Abd Elmaaboud, M., Ashour, A. Ameliorative potential of sitagliptin and/or calcipotriol on lipopolysaccharide-induced Alzheimer's disease. EKB Journal Management System, 2019; 39(2): 191-203. doi: 10.21608/besps.2019.11331.1018

Ameliorative potential of sitagliptin and/or calcipotriol on lipopolysaccharide-induced Alzheimer's disease

Bulletin of Egyptian Society for Physiological Sciences
Article 5, Volume 39, Issue 2, December 2019, Page 191-203  XML PDF (855.06 K)
Document Type: Original Article
DOI: 10.21608/besps.2019.11331.1018
View on SCiNiTO View on SCiNiTO
Authors
Ahmed Kabel1; hany mohammad borg email 2; Maaly Abd Elmaaboud1; Ahmed Ashour3
1Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
2faculty of medicine, kafrelsheikh university
3Biomedical Dental Sciences Department, Faculty of Dentistry, Dammam University, Saudi Arabia Anatomy and Embryology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Abstract
Background: Alzheimer's disease (AD) is a progressive neuropsychiatric disorder that causes dementia. It mostly affects people older than 65 years. The exact mechanisms of AD are not fully understood but affection of apoptosis, oxidative stress and neuroinflammation may be contributing factors. Aim: To evaluate the ability of sitagliptin and/or calcipotriol to attenuate lipopolysaccharide (LPS)-induced AD in mice and to elucidate their possible mechanisms of action. Methods: Sixty male Balb/c mice were divided into 6 equal groups: Control; LPS; LPS + carboxymethyl cellulose; LPS + Sitagliptin; LPS + Calcipotriol; and LPS + Sitagliptin + Calcipotriol group. Behavioral tests, tissue catalase (CAT), superoxide dismutse (SOD) and thiobarbituric acid derivatives (TBARS) were assessed. Also, tissue transforming growth factor beta-1 (TGF-β1), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were determined. Parts of the hippocampus were subjected to histopathological, immunohistochemical and electron microscopic examination. Results: Administration of sitagliptin and/or calcipotriol prior to LPS injection induced significant increase in the recognition index, tissue CAT and SOD associated with significant decrease in tissue TBARS, TNF-α, IL-6 and TGF-β1 and significant improvement of the histopathological, immunohistochemical and electron microscopic picture compared to LPS group. These changes were significant in sitagliptin/calcipotriol combination group compared to the use of each of these drugs alone. Conclusion: Sitagliptin/calcipotriol combination might represent a new therapeutic modality for amelioration of Alzheimer’s disease.
Keywords
Sitagliptin; Calcipotriol; lipopolysaccharide; Alzheimer's disease; Mice
Statistics
Article View: 414
PDF Download: 304