IN VIVO WOUND HEALING AND IN VITRO ANTI- ANTIOXIDANT ACTIVITY EVALUATION OF COTULA CINEREA
LAKACHE, Z., Sadallah, M., Aliboudhar, H., HACIB, H., abdelkrim, K., TOUNSSI, H. (2024). IN VIVO WOUND HEALING AND IN VITRO ANTI- ANTIOXIDANT ACTIVITY EVALUATION OF COTULA CINEREA. EKB Journal Management System, 47(1), 141-150. doi: 10.21608/bfsa.2023.220458.1798
Zineb LAKACHE; Mohcene Sadallah; Hamza Aliboudhar; Hinda HACIB; kameli abdelkrim; Hassina TOUNSSI. "IN VIVO WOUND HEALING AND IN VITRO ANTI- ANTIOXIDANT ACTIVITY EVALUATION OF COTULA CINEREA". EKB Journal Management System, 47, 1, 2024, 141-150. doi: 10.21608/bfsa.2023.220458.1798
LAKACHE, Z., Sadallah, M., Aliboudhar, H., HACIB, H., abdelkrim, K., TOUNSSI, H. (2024). 'IN VIVO WOUND HEALING AND IN VITRO ANTI- ANTIOXIDANT ACTIVITY EVALUATION OF COTULA CINEREA', EKB Journal Management System, 47(1), pp. 141-150. doi: 10.21608/bfsa.2023.220458.1798
LAKACHE, Z., Sadallah, M., Aliboudhar, H., HACIB, H., abdelkrim, K., TOUNSSI, H. IN VIVO WOUND HEALING AND IN VITRO ANTI- ANTIOXIDANT ACTIVITY EVALUATION OF COTULA CINEREA. EKB Journal Management System, 2024; 47(1): 141-150. doi: 10.21608/bfsa.2023.220458.1798

IN VIVO WOUND HEALING AND IN VITRO ANTI- ANTIOXIDANT ACTIVITY EVALUATION OF COTULA CINEREA

Bulletin of Pharmaceutical Sciences Assiut University
Article 8, Volume 47, Issue 1, June 2024, Page 141-150  XML PDF (587.85 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.220458.1798
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Authors
Zineb LAKACHE email 1; Mohcene Sadallah2; Hamza Aliboudharorcid 3; Hinda HACIB1; kameli abdelkrim4; Hassina TOUNSSI1
1Laboratory of Ethnobotany and Natural Substances, ENS-Kouba, Algiers, Algeria
2ENS kouba
3USTHB, Laboratory of Functional Organic Analysis, Faculty of Chemistry, University of Sciences and Technology Houari Boumediene, El Bab-Ezzouar, Algiers, Algeria
4Laboratory of Ethnobotanyand Natural Substances, ENS-Kouba, Algiers
Abstract
The objective of this research was to identify the primary constituents of the essential oil obtained from Cotula cinerea (Delile) Vis. through the process of hydrodistillation. Additionally, the study aimed to explore the oil's in vivo wound healing properties and its in vitro antioxidant capabilities. Several compounds were identified in the essential oil, including thujone, santolina triene, camphor, and 1,8-cineole. To assess its wound healing potential, the essential oil was topically applied to induced wounds in mice, resulting in a notable acceleration of wound healing and repair, with a reported rate of 93.2 ± 0.7%. Furthermore, the research included an evaluation of the essential oil's analgesic activity, which was assessed by administering intraperitoneal injections of acetic acid to mice. Moreover, the antioxidant activity of the essential oil was assessed through the ferric reduction antioxidant power and DPPH scavenging assay. The findings from these antioxidant tests revealed that the essential oil extracted from Cotula cinerea exhibited the ability to reduce iron and scavenge DPPH radicals effectively. These results underscore the bioactive characteristics of Cotula cinerea essential oil and its potential for synergistic effects. Consequently, Cotula cinerea shows promise as a natural source of biologically active compounds with therapeutic potential for wound healing. These discoveries suggest that Cotula cinerea could serve as a viable alternative to synthetic wound treatment medications in the future pharmaceutical industry.
Keywords
Cotula cinerea; antioxidant, wound healing
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