Synthesis, characterization, biological, anticancer and antialzahimar activities studies of ternary pd(II) complexes | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 4, April 2024, Page 523-531 PDF (621.42 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2023.236011.8603 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Lamis omar abo baker1; Walaa H Mahmoud2; Abeer Taha3; Ahmed Abdo El-Sherif  2
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| 1Modern academy for engineering | ||||
| 2Faculty of science, Cairo university | ||||
| 3chemistry, faculty of science, Cairo university | ||||
| Abstract | ||||
| This paper details the synthesis and spectral characterization of novel Pd (II) coordination ternary metal complexes. These complexes are formed using Cefradine as the primary ligand and aromatic amines as secondary ligands. The identification of these new ternary metal complexes involves a comprehensive array of spectrophotometric and physico-chemical analyses, including elemental analysis, infrared spectroscopy (IR), proton nuclear magnetic resonance (1H NMR) spectroscopy, melting point determination, conductivity measurements, mass spectrometry, and thermal analysis (TG and DTG). Furthermore, the antimicrobial activity of these complexes was assessed against a range of microorganisms, including Gram-positive bacteria such as Bacillus subtilis and Staphylococcus aureus, Gram-negative bacteria including Salmonella species and E. coli, as well as fungi like Candida albicans and Aspergillus fumigatus. To gauge their effectiveness, the complexes were compared to well-known standards in the field: amikacin, an antibacterial agent, and ketoconazole, an antifungal agent. Remarkably, the Pd (II) ternary complexes exhibited noteworthy activity as potential anti-Alzheimer's drugs. Additionally, the paper explores the anticancer properties of the ligands and their corresponding metal complexes using viability assays against human cancer cells (MCF-7 cells). These prepared palladium complexes, which demonstrate high selectivity for acetylcholinesterase (AChE), warrant further investigation as potential candidates for the treatment of early-stage Alzheimer's disease symptoms. | ||||
| Keywords | ||||
| Cefradine; ternary complexes; thermogravimetric analyses; Antibacterial activity; anticancer activity; anti-alzahimar drugs | ||||
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