EXPERIMENTAL STUDIES ON THE PATHOGENESIS OF HAEMOPH1LUS SOMNUS INFECTION IN LABORATORY ANIMALS | ||||
| Egyptian Journal of Agricultural Research | ||||
| Article 24, Volume 79, Issue 4, October 2001, Page 1595-1604 PDF (3.04 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejar.2001.320942 | ||||
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| Authors | ||||
| MOHAMED A. WAHBAH1; MOHAMED E. ESSMAIL1; SALEH M. EL-AYOUBY2 | ||||
| 1Animal Reproduction Research Institute, Agricultural Research Centre, Ministry of Agriculture, Giza, Egypt | ||||
| 2Serum and Vaccine Research Institute, Agricultural Research Centre, Ministry of Agriculture, Giza, Egypt | ||||
| Abstract | ||||
| A total of 466 cows and 286 buffaloes, suffering from endometritis, metritis, retained placenta, and pyometra were investigated to isolate and identify the causative agent. Moreover, the pathogenicity of the isolate was studied in guinea pigs and rats which were intraperitoneally (IP) or intracerebrally (IC) injected with 0.5 ml of 24 hours bactothiol broth culture. Specimens from the uterus, brain, kidneys, lungs, and spleen of the inoculated laboratory animals were collected and fixed in 10% neutral buffered formol saline for histopathological examination. Haemophilus somnus was isolated from cows and buffaloes showing retained placenta and pyometra and from cows suffering endometritis and abortion with overall percentages of 4.93 for cows and 1.75 for buffaloes. The encountered lesions in guinea pigs were hemorrhages and congestion, besides degeneration of the internal organs. In rats, the lesions were nearly similar to those in guinea pigs besides oedematous and congested uterine lamina propria, demyelination of the brain, and hemorrhagic and emphysematous lungs. | ||||
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