Role of autophagy in the Title aetiopathogenesis of premature graying of hair: a narrative review of literature
Ali, D., Abdelmaged, W., amr, K., Abdel Hamid, A., ahmed, H. (2024). Role of autophagy in the Title aetiopathogenesis of premature graying of hair: a narrative review of literature. EKB Journal Management System, 28(1), 6-10. doi: 10.21608/smj.2023.227935.1407
Dina Ayman Ali; Wafaa Mohamed Abdelmaged; khaleda amr; Amr Abdelhamed Abdel Hamid; hoda ahmed. "Role of autophagy in the Title aetiopathogenesis of premature graying of hair: a narrative review of literature". EKB Journal Management System, 28, 1, 2024, 6-10. doi: 10.21608/smj.2023.227935.1407
Ali, D., Abdelmaged, W., amr, K., Abdel Hamid, A., ahmed, H. (2024). 'Role of autophagy in the Title aetiopathogenesis of premature graying of hair: a narrative review of literature', EKB Journal Management System, 28(1), pp. 6-10. doi: 10.21608/smj.2023.227935.1407
Ali, D., Abdelmaged, W., amr, K., Abdel Hamid, A., ahmed, H. Role of autophagy in the Title aetiopathogenesis of premature graying of hair: a narrative review of literature. EKB Journal Management System, 2024; 28(1): 6-10. doi: 10.21608/smj.2023.227935.1407

Role of autophagy in the Title aetiopathogenesis of premature graying of hair: a narrative review of literature

Sohag Medical Journal
Volume 28, Issue 1, 2024, Page 6-10  XML PDF (467.57 K)
Document Type: Review Article
DOI: 10.21608/smj.2023.227935.1407
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Authors
Dina Ayman Ali email 1; Wafaa Mohamed Abdelmagedorcid 2; khaleda amr3; Amr Abdelhamed Abdel Hamid4; hoda ahmed3
1Dermatology, medicine, sohag university, sohag, egypt
2Department of dermatology, venereology and andrology, faculty of medicine, sohag university, sohag, Egypt
3EgyptMedical Molecular Genetics Department, Human Genetics & Genome Research Division (HGGR), National Research Centre (NRC), Cairo 12622, Egypt
4Department of dermatology, venereology and andrology, Faculty of medicine, Sohag university, Sohag, Egypt
Abstract
Premature graying of hair (PGH) is a commonly known condition causing significant psychological stress and cosmetic disfigurement. There is unclear significant data available on the clinical profile and pathogenesis. PGH is caused by various exogenous and endogenous factors. There are many causative factors genetic or heredity, oxidative stress from ultraviolet rays, pollution, emotional factors, and inflammatory causes. Also, other environmental factors , drugs, smoking, trace elements, and nutritional deficiency, may play a role in PHG Autophagy may play a significant role in PGH. Many factors have been established to explain the etiopathogenesis of PGH, yet the exact mechanism is still unclear. Also, many treatment modalities have been applied with unsatisfactory results. This review article aims to optimize the most recent and accepted concepts on etiopathogenesis and pathophysiology of PGH and the relation between autophagy and its corresponding genes which may help in finding the best lines of management with the most satisfactory outcomes.
Keywords
Premature graying of hair; etiopathogenesis; autophagy
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