The Effect of Nitroglycerin in Testicular Histopathology, Reproductive Hormones and Testicular Oxidative Stress in Adolescent Rats
Koşal, V., Okulmuş, &., Koçak, Y., Keleş, &., Başbuğan, Y., Ceylan, N. (2023). The Effect of Nitroglycerin in Testicular Histopathology, Reproductive Hormones and Testicular Oxidative Stress in Adolescent Rats. EKB Journal Management System, (), -. doi: 10.21608/mvmj.2023.228652.1146
Volkan Koşal; Çağlar Okulmuş; Yılmaz Koçak; Ömer Faruk Keleş; Yıldıray Başbuğan; Nesrin Ceylan. "The Effect of Nitroglycerin in Testicular Histopathology, Reproductive Hormones and Testicular Oxidative Stress in Adolescent Rats". EKB Journal Management System, , , 2023, -. doi: 10.21608/mvmj.2023.228652.1146
Koşal, V., Okulmuş, &., Koçak, Y., Keleş, &., Başbuğan, Y., Ceylan, N. (2023). 'The Effect of Nitroglycerin in Testicular Histopathology, Reproductive Hormones and Testicular Oxidative Stress in Adolescent Rats', EKB Journal Management System, (), pp. -. doi: 10.21608/mvmj.2023.228652.1146
Koşal, V., Okulmuş, &., Koçak, Y., Keleş, &., Başbuğan, Y., Ceylan, N. The Effect of Nitroglycerin in Testicular Histopathology, Reproductive Hormones and Testicular Oxidative Stress in Adolescent Rats. EKB Journal Management System, 2023; (): -. doi: 10.21608/mvmj.2023.228652.1146

The Effect of Nitroglycerin in Testicular Histopathology, Reproductive Hormones and Testicular Oxidative Stress in Adolescent Rats

Mansoura Veterinary Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 13 October 2023  XML
Document Type: Original Articles
DOI: 10.21608/mvmj.2023.228652.1146
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Authors
Volkan Koşal email orcid 1; Çağlar Okulmuş2; Yılmaz Koçak3; Ömer Faruk Keleş4; Yıldıray Başbuğan5; Nesrin Ceylan6
1Department of Artificial Insemination, Faculty of Veterinary, Van Yuzuncu Yil University, Van, Turkey
2Department of Biochemistry, Izmir/Bornova Veterinary Control Institute, TR-35030 Izmir, TURKEY
3Physical Therapy and Rehabilitation, Faculty of Health Sciences, Van Yuzuncu Yil University, TR-65080, Van, Turkey
4Department of Pathology, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, TR-65080, Van, TURKEY
5Department of Internal Medicine, Faculty of Veterinary Medicine, Van Yuzuncu Yıl University, TR-65080, Van, TURKEY
6Department of Pediatric Neurology University of Health Sciences, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, TR-06080, Ankara, Turkey
Abstract
Objective: Nitroglycerin (NTG) demonstrates a vasodilation effect by acting on vascular smooth muscles. The exact impact of vasodilation on the testes is not fully understood. The aim of this study is to investigate the effects of NTG on the testes before the onset of spermatogenesis and reproductive activities in adolescent rats.

Animals: Average of 45 days old male Albino Wistar rats were used.

Design: Two different groups were formed: an adolescent control group and an adolescent NTG group (10mg/kg, 5 days).

Results: At the end of the study, testicular oxidative stress (MDA, CAT, AOPP, NO), reproductive hormones (FSH, LH, Testosterone), and testicular histopathology were examined. In comparison to the control group, the testicular tissue MDA and NO levels in the NTG group were significantly increased (p<0.05), while CAT activity was decreased (p<0.05). Upon examining reproductive hormone levels, an increase in FSH and LH was observed in the NTG group (p<0.05), while testosterone levels remained unchanged. Histopathological examination revealed the onset of changes in the tubulus seminiferus contortus of NTG group rats.

Conclusion and clinical relevance: As a result of this study, it was determined that the use of NTG in adolescent male rats increases testicular oxidative stress and affects reproductive hormone synthesis.
Keywords
Adolescent; Male; Nitroglycerin; Rat; Testis
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