Association of rs6695096 Single Nucleotide Polymorphism of Human Mannose Binding Lectin Associated Serine Protease 2 (MASP2) Gene Locus and MASP2 Serum Level with Systemic Lupus Erythematosus | ||||
Egyptian Journal of Medical Microbiology | ||||
Volume 32, Issue 4, October 2023, Page 85-94 PDF (575.32 K) | ||||
Document Type: New and original researches in the field of Microbiology. | ||||
DOI: 10.21608/ejmm.2023.321765 | ||||
View on SCiNiTO | ||||
Authors | ||||
Dina S. Abu Shabana 1; Mohamed R. Mohamed 2; Dina M. Erfan 1; Shereen E. Taha 1; Yasmin M. Ahmed 1 | ||||
1Medical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University, Egypt | ||||
2Rheumatology Department, Faculty of Medicine, Ain Shams University, Egypt | ||||
Abstract | ||||
Background: Systemic lupus erythematosus (SLE) represents one of the most challenging autoimmune diseases with high morbidities. MASP2 is a central enzyme in the lectin pathway of complement that has a potential role in the disease pathogenesis. This makes it a potential biomarker of interest in correlation with the disease activity. Objectives: The aim of the study was to assess the association between MASP2 serum level and SLE disease activity as well as the association between MASP2 rs 6695096 SNP and SLE. Methodology: Thirty-five patients diagnosed as SLE and Fifteen healthy control subjects were included in this study. The serum level of MASP2 was measured by ELISA and the rs 6695096 SNP of MASP2 was detected by PCR for both groups. Results: MASP2 serum levels were significantly lower in patients compared to control group (p=0.009). In addition, serum MASP2 level was negatively correlated with the disease activity (p=0.002). TC genotype was significantly correlated with pleural effusion (p=0.007) and hematuria (p=0.031). No significant correlation could be observed between MASP2 genotypes and both SLEDAI score and MASP2 serum level. Conclusion: Decreased MASP2 level could be a promising biomarker of SLE disease activity. | ||||
Keywords | ||||
Systemic lupus erythematosus; MASP2; SNP | ||||
Statistics Article View: 133 PDF Download: 88 |
||||