Elevated Cellular-microparticles Expressing Platelets and Endothelial Markers in Cardio-vascular Ischemic Infarction (A Possible New Challenge for Early Diagnosis)
Khalil, M., Abdel-Aziz, A., Ezzat, M., Abdel-Ghafar, N., Mahmoud, E. (2019). Elevated Cellular-microparticles Expressing Platelets and Endothelial Markers in Cardio-vascular Ischemic Infarction (A Possible New Challenge for Early Diagnosis). EKB Journal Management System, 11(1), 63-72. doi: 10.21608/eajbsd.2019.32202
Mohamed W. Khalil; Aymn M. Abdel-Aziz; Mostafa A. Ezzat; Noha K. Abdel-Ghafar; Esraa A. Mahmoud. "Elevated Cellular-microparticles Expressing Platelets and Endothelial Markers in Cardio-vascular Ischemic Infarction (A Possible New Challenge for Early Diagnosis)". EKB Journal Management System, 11, 1, 2019, 63-72. doi: 10.21608/eajbsd.2019.32202
Khalil, M., Abdel-Aziz, A., Ezzat, M., Abdel-Ghafar, N., Mahmoud, E. (2019). 'Elevated Cellular-microparticles Expressing Platelets and Endothelial Markers in Cardio-vascular Ischemic Infarction (A Possible New Challenge for Early Diagnosis)', EKB Journal Management System, 11(1), pp. 63-72. doi: 10.21608/eajbsd.2019.32202
Khalil, M., Abdel-Aziz, A., Ezzat, M., Abdel-Ghafar, N., Mahmoud, E. Elevated Cellular-microparticles Expressing Platelets and Endothelial Markers in Cardio-vascular Ischemic Infarction (A Possible New Challenge for Early Diagnosis). EKB Journal Management System, 2019; 11(1): 63-72. doi: 10.21608/eajbsd.2019.32202

Elevated Cellular-microparticles Expressing Platelets and Endothelial Markers in Cardio-vascular Ischemic Infarction (A Possible New Challenge for Early Diagnosis)

Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry
Article 5, Volume 11, Issue 1, June 2019, Page 63-72  XML PDF (1.08 MB)
Document Type: Original Article
DOI: 10.21608/eajbsd.2019.32202
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Authors
Mohamed W. Khalil1; Aymn M. Abdel-Aziz1; Mostafa A. Ezzat1; Noha K. Abdel-Ghafar1; Esraa A. Mahmoud2
1Department of Zoology .Faculty of Science .Fayoum University El-Fayoum Egypt
2Fayoum University Hospital. Fayoum University El-Fayoum Egypt
Abstract
Cellular microparticles are plasma membrane vesicles of 0.05). A cutoff value for the expression of CD61p as a marker of thrombotic MI was suggested to be (58.70) revealed (70%) sensitivity and (85%) specificity and as regards CD 62E/61, taking (22.25) as a cut-off point revealed (60%) sensitivity and (95%) specificity using ROC curve statistical method. In conclusions, the antithrombotic properties of low dose antiplatelet or anticoagulant therapy are not strong enough to suppress shedding of the microparticles. A cut off value for expression of CD61 and coexpression CD 62E/61 in MI patients can contribute to the clinical applications as using MP assay in early diagnosis of thrombotic propensity, monitoring of anticoagulant therapy, and detection the risk of ischemic heart diseases in high-risk patients.
Keywords
Platelet and Endothelial microparticles; myocardial infarction; Anticoagulant treatment
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