Synthesis and antimicrobial evaluation of some Schiff bases and their metal complexes against bacteria and fungi | ||||
| Benha Journal of Applied Sciences | ||||
| Article 12, Volume 7, Issue 12, December 2022, Page 109-124 PDF (775.34 K) | ||||
| Document Type: Original Research Papers | ||||
| DOI: 10.21608/bjas.2022.322050 | ||||
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| Authors | ||||
| Maram Ahmed Ali1; Iman Aly Gad El-Karim1; Mohamed S. Behalo1; Nabel A. Negm2 | ||||
| 1Chemistry department, Faculty of Science, Benha University | ||||
| 2Petrochemicals department, Egyptian petroleum research institute | ||||
| Abstract | ||||
| Finding novel active compounds to solve the problem of microbial resistance of antibiotic is a matter of urgency. That’s why several drugs were produced from many precursors. Schiff bases are a good base for synthesis several antimicrobial compounds . This work investigates biological activities as cytotoxicity and antimicrobial properties of some Schiff base compounds which synthesized by coupling reaction between two aromatic amines namely: aminoantipyrine, and 4-aminophenol by two aldehydes namely: vanillin and gluteraldehyde. Metal complexes of the obtained four Schiff bases were prepared throughout reaction with copper and ferric ions. FTIR, atomic absorption spectroscopy and 1H-NMR measurements. microbial evaluation of Schiff bases and metal complexes was tested against various microorganisms including: gram +ve and gram -ve bacterial strains utilizing the diameter of inhibition zone, and minimum inhibitory concentration procedures. Showing that the cytotoxic effect of metal complexes is more than the ligand form . Furthermore, Ferric metal complexes exhibited significant inhibition than the copper complexes, which was attributed to the ability of oxidation-reduction tendency of Fe3+ ions than Cu2+. The gram genera of the bacterial strains played a significant role on their resistivity towards the tested antimicrobial compounds, own to the nature of their cellular membranes. | ||||
| Keywords | ||||
| Schiff base; metal complexes; antimicrobial activity; cytotoxic assessment; gram-positive bacteria; gram-negative bacteria | ||||
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