Prognostic Effect of Nodular and Infiltrating Tumor deposits of colorectal carcinoma and its relation to neoadjuvant therapy; a retrospective study | ||||
| SECI Oncology Journal | ||||
| Volume 11, Issue 4, October 2023, Page 275-289 | ||||
 View on SCiNiTO | ||||
| Abstract | ||||
| Objective: This study aimed to assess correlation between tumor deposits and clinicopathological characteristics of colorectal cancer, evaluate the relationship between tumor deposits and prognosis of colorectal cancer (CRC) patient and the relationship between tumor deposits and neoadjuvant chemotherapy. Methods: One hundred and thirty three cases with stage I–IV CRC who underwent primary tumor resection for operable cases in the period between January 2017 and December 2019 and followed up until June 2022 were included in this study. Cases were selected from the registry of the Pathology Department at South Egypt Carcinoma Institute (SECI). The H & E stained slides were examined initially and the tumors were staged according to AJCC TNM classification eighth edition. Result: Tumor deposit (TD) was detected in 39 (29.3%) of the studied cases, while 94 (70.7%) cases were negative for TDs. Statistical significance association was detected between the presence of TDs and tumor invasion and lymph node (LN) metastasis (P=0.004 and P=0.000). There was statistical significance between TDs and prognosis as follow; presence of TDs decreases the overall survival and DFS (associated with poor prognosis). Both are inversely affected (decreased) (P=0.000, P=0.006) respectively Conclusion: this study shows that tumor deposit is an independent prognostic factor in colorectal carcinoma patients that affects negatively both OS and DFS with significant association between it and lymphovascular invasion (LVI), perineural invasion (PNI), LN metastasis, tumor invasion. Furthermore, presence of both TDs and LN metastases confers additive risk. | ||||
| Keywords | ||||
| Colorectal carcinoma; tumor deposit; lymph node; neoadjuvant therapy; prognosis | ||||
|
Supplementary Files
|
||||
|
Statistics Article View: 79 |
||||
