The combination of atorvastatin with Proanthocyanidin enhances antioxidant and reactive oxidative stress on HepG2 hepatocellular Carcinoma Cells. | ||||
| Benha Veterinary Medical Journal | ||||
| Volume 45, Issue 1, October 2023, Page 114-117 PDF (1.04 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bvmj.2023.222217.1678 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
dina soror maria  1; Elsayed Salim* 2; Afaf Abd El-Magid* 1
| ||||
| 1Biochemistry Department, Faculty of Veterinary Medicine, Moshtohor, Banha University. | ||||
| 2Department of Zoology, Research Laboratory of Molecular Carcinogenesis, Faculty of Science, Tanta University, Tanta 31527, Egypt | ||||
| Abstract | ||||
| The purpose of this study was to measure the antioxidant state and reactive oxidative stress in the HPG2 cell line in order to explore the effects of Taxol, Atorvastatin, and proanthocynadin. In this study, the effects of Atorvastatin, a novel 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and Proanthocynadine, the most prevalent polyphenol class in the human diet, on a range of metabolic diseases and chemotherapeutic effects were investigated, Taxol, a chemothrbutic drug is substance derived from the bark and trunk of the Yew Pacific tree, was shown to assist induce and enhance tubulin polymerization and assembly while also preventing its depolymerization effects on oxidative stress and antioxidant enzymes. Taxol, Atorvastatin, and Proanthcyanidine inhibited the viability of HepG2 cells in a time- and dose-dependent manner, and induced a significant increase in antioxidant enzyme concentrations of superoxide dismutase (SOD), catalase, glutathione reductase, and malondialdehyde (MDA) in all treated groups compared to untreated cells. | ||||
| Keywords | ||||
| HpG2; Taxol; Atorvastatin; Proanthocynadin; Antioxidants | ||||
|
Statistics Article View: 58 PDF Download: 55 |
||||
