Serum Irisin levels in adult type 2 Diabetic patients with Microvascular Complications | ||||
| Zagazig University Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 28 October 2023 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2023.243444.2967 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Shimaa Mahmoud Abd El-Rahman  1; Ebtehag Helmy Hassan2; Ahmed Abdulsaboor 3; Islam Maher4
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| 1Clinical Pathology Department, Faculty of Medicine, Zagazig university | ||||
| 2Clinical pathology Department, Faculty of medicine, Zagazig University, Zagazig, Egypt | ||||
| 3Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||||
| 4Internal Medicine-Zagazig University | ||||
| Abstract | ||||
| Background: Type 2 diabetes mellitus (T2DM) is a multisystem chronic disease that has attained an epidemic scale. The microvasculature is harmed by persistent hyperglycemia, which eventually results in diabetic nephropathy, neuropathy, and retinopathy. Irisin was identified as a myokine that can affect several metabolic pathways. Objectives: To investigate the value of irisin measurement in early detection of microvascular complications in adult T2DM patients. Subjects and methods: This case-control study included 90 subjects divided into 3 equal groups: Group I of 30 healthy volunteers, group II of 30 adult T2DM patients without complications, and group III 30 adult T2DM patients with microvascular complications. All studied subjects were subjected to clinical assessment and lab investigations that included routine parameters, cystatin C, urine albumin creatinine ratio as well as irisin measurement. Results: Irisin was significantly lower in the patient groups. It showed moderate performance (AUC 0.674, p-value 0.007) with 70% sensitivity and 63.3% specificity for detection of microvascular complications. Conclusion: Irisin has a connection to T2DM, with moderate performance in detection of micro-vascular complications. Irisin could, therefore, be used to early of diabetic microvascular complications in adult T2DM patients | ||||
| Keywords | ||||
| Irisin; microvascular complications; type 2 diabetes | ||||
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