Ameliorating Effect of Black Chia (Salvia Hispanica L.) Oil and/ or Peppermint (Mentha Piperita L.) Oil on Neurological Effects Induced by Lead Acetate in Growing Albino Rats
Helal, H., Mohamed, K., Ali, A., Abd El-Fattah, B. (2024). Ameliorating Effect of Black Chia (Salvia Hispanica L.) Oil and/ or Peppermint (Mentha Piperita L.) Oil on Neurological Effects Induced by Lead Acetate in Growing Albino Rats. EKB Journal Management System, 67(5), 587-595. doi: 10.21608/ejchem.2023.240111.8705
Hadeer Mahmoud Helal; Kout Elkoloub Abdel Hamid Mohamed; Amina Rashad Ali; Bakinam Ali Abd El-Fattah. "Ameliorating Effect of Black Chia (Salvia Hispanica L.) Oil and/ or Peppermint (Mentha Piperita L.) Oil on Neurological Effects Induced by Lead Acetate in Growing Albino Rats". EKB Journal Management System, 67, 5, 2024, 587-595. doi: 10.21608/ejchem.2023.240111.8705
Helal, H., Mohamed, K., Ali, A., Abd El-Fattah, B. (2024). 'Ameliorating Effect of Black Chia (Salvia Hispanica L.) Oil and/ or Peppermint (Mentha Piperita L.) Oil on Neurological Effects Induced by Lead Acetate in Growing Albino Rats', EKB Journal Management System, 67(5), pp. 587-595. doi: 10.21608/ejchem.2023.240111.8705
Helal, H., Mohamed, K., Ali, A., Abd El-Fattah, B. Ameliorating Effect of Black Chia (Salvia Hispanica L.) Oil and/ or Peppermint (Mentha Piperita L.) Oil on Neurological Effects Induced by Lead Acetate in Growing Albino Rats. EKB Journal Management System, 2024; 67(5): 587-595. doi: 10.21608/ejchem.2023.240111.8705

Ameliorating Effect of Black Chia (Salvia Hispanica L.) Oil and/ or Peppermint (Mentha Piperita L.) Oil on Neurological Effects Induced by Lead Acetate in Growing Albino Rats

Egyptian Journal of Chemistry
Volume 67, Issue 5, May 2024, Page 587-595  XML PDF (693.6 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.240111.8705
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Authors
Hadeer Mahmoud Helal email 1; Kout Elkoloub Abdel Hamid Mohamed2; Amina Rashad Aliorcid 3; Bakinam Ali Abd El-Fattah2
1Biochemistry and nutrition, faculty of women for arts,science and education, ain shams University, Cairo, Egypt
2Biochemistry and Nutrition Department, Faculty of Women for Arts, Science and Education, Ain Shams university.
3Department of Pesticide Chemistry, National research centre
Abstract
Lead poisoning has been classified as a non-traumatic brain injury. Exposure to lead during childhood may result in cognitive changes, memory disorders and requires neurodevelopmental monitoring till early adulthood. The present study investigated the ameliorative effect of black chia oil (COE) peppermint oil (POE) and their mixture against the neurological effects induced by lead acetate (LA) in growing albino rats. Eighty male rats were divided into eight groups, HCG: healthy control group; COCG: Chia oil group; POCG: peppermint oil group; COE+POE: Chia & peppermint oils mixture group; LACG: Lead acetate group; LA+COE: lead acetate + chia oil group; LA+POE: lead acetate+ peppermint oil group; LA+MOsE: lead acetate + chia and peppermint oils mixture group. Biochemical parameters including neural cell markers (BTChe, 5-HT and DA), antioxidant (SOD, CAT, TAC, GST and GPx), inflammatory (TNF-α and IL-6), oxidative stress (MDA), liver enzymes and kidney functions were investigated. Histopathology changes in brain and liver tissues was also detected. Supplementation of COE, POE and their mixture have proved to exerts an ameliorative effect against the neurological and histological disorders resulted from oral lead administration in growing rats. The synergistic effect of peppermint oil with chia oil resulted in a strong ameliorating effect against lead-intoxication.
Keywords
Neurological disorders; Black chia oil; Peppermint volatile oil; Lead acetate; Biochemical changes; Synergistic action
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