Anticancer Potential of Blue-Green Algae Extract (Spirulina Plantesis) and Curcumin Nanoparticles on Ehrlich Ascites Carcinoma–Bearing Mice
Hamdy, S., Moawad, B., Mohamed, H., Shabaan, A., Sayed, O. (2024). Anticancer Potential of Blue-Green Algae Extract (Spirulina Plantesis) and Curcumin Nanoparticles on Ehrlich Ascites Carcinoma–Bearing Mice. EKB Journal Management System, 67(5), 335-346. doi: 10.21608/ejchem.2023.238561.8657
Soha M. Hamdy; Basma M. Moawad; Heba R. Mohamed; Amany M. Shabaan; Ola N. Sayed. "Anticancer Potential of Blue-Green Algae Extract (Spirulina Plantesis) and Curcumin Nanoparticles on Ehrlich Ascites Carcinoma–Bearing Mice". EKB Journal Management System, 67, 5, 2024, 335-346. doi: 10.21608/ejchem.2023.238561.8657
Hamdy, S., Moawad, B., Mohamed, H., Shabaan, A., Sayed, O. (2024). 'Anticancer Potential of Blue-Green Algae Extract (Spirulina Plantesis) and Curcumin Nanoparticles on Ehrlich Ascites Carcinoma–Bearing Mice', EKB Journal Management System, 67(5), pp. 335-346. doi: 10.21608/ejchem.2023.238561.8657
Hamdy, S., Moawad, B., Mohamed, H., Shabaan, A., Sayed, O. Anticancer Potential of Blue-Green Algae Extract (Spirulina Plantesis) and Curcumin Nanoparticles on Ehrlich Ascites Carcinoma–Bearing Mice. EKB Journal Management System, 2024; 67(5): 335-346. doi: 10.21608/ejchem.2023.238561.8657

Anticancer Potential of Blue-Green Algae Extract (Spirulina Plantesis) and Curcumin Nanoparticles on Ehrlich Ascites Carcinoma–Bearing Mice

Egyptian Journal of Chemistry
Volume 67, Issue 5, May 2024, Page 335-346  XML PDF (925.81 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.238561.8657
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Authors
Soha M. Hamdy1; Basma M. Moawad email 1; Heba R. Mohamed2; Amany M. Shabaan1; Ola N. Sayed1
1Chemistry Department, Biochemistry Division, Faculty of Science, El Fayoum University, El- Fayoum, Egypt.
2Zoology Department, Faculty of Science, El Fayoum University, El- Fayoum, Egypt.
Abstract
Abstract

This research was accomplished to identify the possibility of preventing cancer by Spirulina plantesis (SP) and curcumin nanoparticles (Cur-NPs) being natural substances in the EAC model. 110 male mice were split up randomly into group (I): healthy control; group (II): mice received SP; group (III): mice received Cur-NPs; group IV: mice administrated with both SP and Cur-NPs; group V: EAC group; group VI: SP Protective (Pr) group; group VII: SP Therapeutic (Tr) group; group VIII: Cur-NPs Pr group; group IX: Cur-NPs Tr group; group X: SP & Cur-NPs Pr group; group In comparison to the control group, the biochemical assays throughout this study exhibited an extremely significant rise in serum and hepatic MDA, ALT, and AST levels and a greatly marked drop in levels of TAC in the EAC group. In contrast, administration of Cur-Nps alone or combined with SP results in a significant reduction and improvement in their levels. The histological and immunohistochemical findings confirm the biochemical observations since the liver's histology and immunohistochemistry were improved by SP and Cur-NPs.
Keywords
Keywords: Spirulina plantesis (SP); Curcumin nanoparticles (Cur-Nps); Ehrlich ascites carcinoma (EAC)
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