Nontuberculous mycobacterial infection in patients with bronchiectasis. A single-center study | ||||
| Microbes and Infectious Diseases | ||||
| Article 17, Volume 5, Issue 1, February 2024, Page 155-167 PDF (913.43 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2023.241803.1633 | ||||
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| Authors | ||||
Marwa Elmongi1; Mohammed Elkenawy1; Tamer Elhadidy2; Rasha Mokhtar Elnagar   1, 3
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| 1Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||||
| 2Chest medicine department, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||||
| 3Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh, Saudi Arabia | ||||
| Abstract | ||||
| Background: Globally, bronchiectasis-related nontuberculous mycobacterial (NTM) disease is on the rise. The diagnosis of NTM infection is difficult and treatment varies according to NTM species. This study intended to detect the prevalence of NTM in patients with bronchiectasis. Methods: A total of 100 bronchoalveolar lavage (BAL) specimens were collected from patients with adult-onset bronchiectasis attending the chest medicine department, Mansoura University Hospitals (MUH), Egypt between December 2021 and November 2022. Clinical samples were processed to detect NTM isolates by phenotypic methods including microscopic examination, culture on Lowenstein Jensen (LJ) slants, and various biochemical reactions. Positive NTM specimens were further confirmed by multiplex polymerase chain reaction (PCR). Results: Out of 100 patients included in this study, seven cases were positive for NTM in their BAL by conventional methods. Of those, two were confirmed as Mycobacterium kanssasi by multiplex PCR (29%; 2/7) and five (71.4%, 5/7) were unidentified NTM species. NTM infection was significantly associated with old age and immunocompromised status of the patients. Conclusion: Nontuberculous mycobacterial (NTM) lung disease is a common health problem in bronchiectasis and should be routinely examined particularly in old age and individuals with lower immune response. | ||||
| Keywords | ||||
| Atypical mycobacteria; NTM; Bronchiectasis | ||||
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