Correlation Between Cytokine Gene CCL3, miRNA146-B and Otitis Media Patients in AL-Najaf Governorate, Iraq
Al Fatlawi, M., Al Ammar, M., Al Mansoori, Y. (2023). Correlation Between Cytokine Gene CCL3, miRNA146-B and Otitis Media Patients in AL-Najaf Governorate, Iraq. EKB Journal Management System, 15(2), 631-638. doi: 10.21608/eajbsc.2023.325503
Manar M. H. Al Fatlawi; Mahdi H. Al Ammar; Yasir L. H. Al Mansoori. "Correlation Between Cytokine Gene CCL3, miRNA146-B and Otitis Media Patients in AL-Najaf Governorate, Iraq". EKB Journal Management System, 15, 2, 2023, 631-638. doi: 10.21608/eajbsc.2023.325503
Al Fatlawi, M., Al Ammar, M., Al Mansoori, Y. (2023). 'Correlation Between Cytokine Gene CCL3, miRNA146-B and Otitis Media Patients in AL-Najaf Governorate, Iraq', EKB Journal Management System, 15(2), pp. 631-638. doi: 10.21608/eajbsc.2023.325503
Al Fatlawi, M., Al Ammar, M., Al Mansoori, Y. Correlation Between Cytokine Gene CCL3, miRNA146-B and Otitis Media Patients in AL-Najaf Governorate, Iraq. EKB Journal Management System, 2023; 15(2): 631-638. doi: 10.21608/eajbsc.2023.325503

Correlation Between Cytokine Gene CCL3, miRNA146-B and Otitis Media Patients in AL-Najaf Governorate, Iraq

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Volume 15, Issue 2, December 2023, Page 631-638  XML PDF (687.29 K)
Document Type: Original Article
DOI: 10.21608/eajbsc.2023.325503
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Authors
Manar M. H. Al Fatlawi1; Mahdi H. Al Ammar2; Yasir L. H. Al Mansoori3
1Biologist at public health laboratory, Iraq.
2Department of Biology, Faculty of Science, University of Kufa, Iraq.
3University of Kufa, P.O.Box(21), Iraq.
Abstract
The current study aims to detect the gene expression of genes (CCL3, miRNA-b) in Otitis Media patients and healthy persons. This finding included 50 samples collected from healthy subjects and 100 samples from a patient suffering from otitis media who attended Al-Sadr Medical City (ENT Department) in Al-Najaf Governorate during the period from February 2022 to June 2022. The samples had an average age ranging from 5 to 70 years. In this case-control study, the gene expression of these genes was compared in people with Otitis media and healthy people. PCR technique is used. The patient and control groups' samples were amplified using polymerase chain reactions. The results of the molecular study (gene expression) showed a high significant increase in the level of gene expression in patients for the two genes CCL3, miRNA146-b (9.807 ± 1.14 (6.405 ± 0.7576), respectively, compared to the control group, with a high significant difference at P≤0.05.
Keywords
Cytokine genes; CCL3; miRNA146-B; Otitis Media; PCR
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