Does early initiation of anticoagulant therapy minimize the need for maternal respiratory support in COVID-19 positive pregnant women?
Abdel megid, S., Ameen, H., abdel hamid soliman, M., el mahy, M. (2023). Does early initiation of anticoagulant therapy minimize the need for maternal respiratory support in COVID-19 positive pregnant women?. EKB Journal Management System, 1(1), 9-18. doi: 10.21608/arcmed.2023.202815.1022
Salah H Abdel megid; Hany Saad Ameen; Mahmoud mohamed abdel hamid soliman; mohamed el mahy. "Does early initiation of anticoagulant therapy minimize the need for maternal respiratory support in COVID-19 positive pregnant women?". EKB Journal Management System, 1, 1, 2023, 9-18. doi: 10.21608/arcmed.2023.202815.1022
Abdel megid, S., Ameen, H., abdel hamid soliman, M., el mahy, M. (2023). 'Does early initiation of anticoagulant therapy minimize the need for maternal respiratory support in COVID-19 positive pregnant women?', EKB Journal Management System, 1(1), pp. 9-18. doi: 10.21608/arcmed.2023.202815.1022
Abdel megid, S., Ameen, H., abdel hamid soliman, M., el mahy, M. Does early initiation of anticoagulant therapy minimize the need for maternal respiratory support in COVID-19 positive pregnant women?. EKB Journal Management System, 2023; 1(1): 9-18. doi: 10.21608/arcmed.2023.202815.1022

Does early initiation of anticoagulant therapy minimize the need for maternal respiratory support in COVID-19 positive pregnant women?

ARCADEs of MEDICINE
Volume 1, Issue 1, December 2023, Page 9-18  XML PDF (429.51 K)
Document Type: Original Research
DOI: 10.21608/arcmed.2023.202815.1022
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Authors
Salah H Abdel megid email 1; Hany Saad Ameen2; Mahmoud mohamed abdel hamid soliman3; mohamed el mahy2
1obstetrics and Gynecology department , armed forces colege of medicine , Cairo , Egypt
2Obstetrics and Gynecology department ,faculty of medicine , cairo university, cairo , Egypt .
3Obstetrics and Gynecology department , faculty of medicine , cairo university , cairo , Egypt .
Abstract
Background: Thrombosis is an outcome of COVID-19 illness and has prognostic implications. There is no evidence that pregnant women fare worse from SARS-CoV-2 infection than do nonpregnant women of the same age, however there is evidence that pregnant women infected with COVID-19 do worse. Patients with severe COVID19 infection had a better prognosis when treated with anticoagulant therapy with LMWH which is considered the best option for preventive anticoagulation in COVID-19 illness .

Objectives: To measure the association between early vs. late initiation of anticoagulant therapy and the need for maternal respiratory support in pregnant women infected with Covid-19.

Subject and Methods: This study had been carried out at Obstetrics and Gynecology department, Masr El-Gededa military hospital on 100 pregnant women with confirmed Covid-19 infection

Results: Group B had much lower O2 saturation than Group A. Comparing groups A and B, there was a decline in Hb, WBCs, platelets, neutrophils, and lymphocytes in group B. Group B had considerably higher levels of serum creatinine and urea nitrogen than Group A. Group B had greater values for PT, INR, D- dimer, fibrinogen, LDH, CRP, ferritin, parity, and gestational age at infection compared to group A. In terms of breathing, pregnancy, and giving birth, there was a huge discrepancy between the two groups. The majority of patients required immediate CS due to emergencies.

Conclusion: Anticoagulant treatment taken early in the course of a Covid-19 infection in a pregnant woman is superior and more effective, and minimizes the need for maternal respiratory support
Keywords
Anticoagulant; Maternal Respiratory Support; COVID-19; Pregnancy
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