Screening of Arterial Atherosclerosis in JAK2 positive Philadelphia negative myeloproliferative neoplasms among Egyptian patients below 60 years old.
Saeed, A., El Husseiny, N., Mohamed, M., Hafez, H., Khalaf, M., B soryal, G., Abd El-Ghani, S. (2023). Screening of Arterial Atherosclerosis in JAK2 positive Philadelphia negative myeloproliferative neoplasms among Egyptian patients below 60 years old.. EKB Journal Management System, 1(1), 26-31. doi: 10.21608/arcmed.2023.205336.1025
Ahmed Mohamed Saeed; Noha Mohamed El Husseiny; Marwa Salah Mohamed; Hany Hafez; Mohamed Khalaf; George B soryal; Sara El-Sayed Abd El-Ghani. "Screening of Arterial Atherosclerosis in JAK2 positive Philadelphia negative myeloproliferative neoplasms among Egyptian patients below 60 years old.". EKB Journal Management System, 1, 1, 2023, 26-31. doi: 10.21608/arcmed.2023.205336.1025
Saeed, A., El Husseiny, N., Mohamed, M., Hafez, H., Khalaf, M., B soryal, G., Abd El-Ghani, S. (2023). 'Screening of Arterial Atherosclerosis in JAK2 positive Philadelphia negative myeloproliferative neoplasms among Egyptian patients below 60 years old.', EKB Journal Management System, 1(1), pp. 26-31. doi: 10.21608/arcmed.2023.205336.1025
Saeed, A., El Husseiny, N., Mohamed, M., Hafez, H., Khalaf, M., B soryal, G., Abd El-Ghani, S. Screening of Arterial Atherosclerosis in JAK2 positive Philadelphia negative myeloproliferative neoplasms among Egyptian patients below 60 years old.. EKB Journal Management System, 2023; 1(1): 26-31. doi: 10.21608/arcmed.2023.205336.1025

Screening of Arterial Atherosclerosis in JAK2 positive Philadelphia negative myeloproliferative neoplasms among Egyptian patients below 60 years old.

ARCADEs of MEDICINE
Volume 1, Issue 1, December 2023, Page 26-31  XML PDF (307.81 K)
Document Type: Original Research
DOI: 10.21608/arcmed.2023.205336.1025
View on SCiNiTO View on SCiNiTO
Authors
Ahmed Mohamed Saeed email 1; Noha Mohamed El Husseiny2; Marwa Salah Mohamed3; Hany Hafez4; Mohamed Khalaf5; George B soryal6; Sara El-Sayed Abd El-Ghaniorcid 7
1Internal medicine department ,AFCM, Cairo, Egypt
2Hematology department , Armed Forces college of Medicine (AFCM), Cairo, Egypt
3Hematology department, Armed Forces College of Medicine (AFCM),Cairo, Egypt
4Radiology department ,Military Medical Academy , Cairo, Egypt
5Hematology department, Military Medical Academy, Cairo, Egypt
6Hematology department, Military Medical Academy , Cairo, Egypt
7Internal medicine, faculty of medicine Cairo University, Cairo, Egypt Hematology department, AFCM, Cairo, Egypt
Abstract
Background

It has been discovered that patients with myeloproliferative neoplasms (MPNs) have an increased risk of thrombosis in presence of JAk2V617F mutation that causes a thrombophilic phenotype.

Ejection fraction (EF) and lipid profile assessment are accepted as markers of subclinical atherosclerosis and can help the clinician to reclassify the cardiovascular risk of patients into a lower or higher risk category.



Objective

The aim of the study was to identify whether the risk of arterial atherosclerosis increases in MPNs patients below 60 years in comparison to normal population regardless the known risk factor of atherosclerosis as diabetes, Hypertension and smoking.



Methods

The study included 48 patients of MPNs and 48 control samples were selected from the same places .the control were chosen as one by one to match the case in age, sex, smoking, HTN and DM. All the patients were subjected to: history taking and physical examination. Laboratory investigations include CBC and lipid profile. Radiological investigations in form of Trans thoracic Echo for EF assessment.



Results

The MPNs patients Showed statistically significant difference (P value 0.035) in the EF assessment when compared to controls and significant increase in lipid profile (LDL, HDL, TGs) despite similar risk in DM and HTN, With no significant difference between PV and ET cases regarding measurement of EF and lipid profile assessment (p value 0.352). This may point to the main drive for impaired EF and lipid profile is related mainly to JAK2 gene mutation.



Conclusion

JAK2 gene mutation is a risk factor for atherosclerosis.
Keywords
Ejection fraction; lipid profile; Polycythemia Vera; Essential thrombocythemia
Statistics
Article View: 66
PDF Download: 42