Comparison between letrozole treatment before Misoprostol and Misoprostol alone for medical management of missed Abortion | ||||
| Zagazig University Medical Journal | ||||
| Article 38, Volume 30, Issue 1.6, September 2024, Page 3063-3070 PDF (399.83 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2023.246671.2996 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Tomador Elian  1; Azza Abd Elmageid Abd Elhameid2; Mohamed Fathy Abo Hashim3; Ahlam Ahmed Basha 4
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| 1Gynecology and Obstetric Department, Faculty of Medicine, Zagazig University-Egypt | ||||
| 2Obstetric& Gynecology department faculty of medicine - Zagazig university-Egypt | ||||
| 3Obstetric & Gynecology Department-Facutly of Medicine-Zagazig University-Egypt | ||||
| 4Obstetric & Gynecology Department-Faculty of Medicine-Zagazig University, Egypt | ||||
| Abstract | ||||
| Background: It is essential to ascertain and diagnose the optimal treatment protocol for medical abortion. Consequently, it is necessary to evaluate the efficacy of combining letrozole with misoprostol compared to the administration of misoprostol alone in the termination of missed abortions occurring in the first trimester. Methods: The study was done on a total of 88 patients; Group A consisted of a total of 44 individuals who were administered a combination of Letrozole and Misoprostol. A pre-treatment regimen consisting of 5 mg of letrozole administered every 12 hours for a duration of three consecutive days was administered. This was followed by the administration of four tablets of vaginal misoprostol, each containing 200mcg of the active ingredient. An additional dose of misoprostol was administered after a period of three hours, if deemed necessary. Group B consisted of 44 patients who were administered "Misoprostol." A single tablet of folic acid was administered as a placebo every 12 hours for three consecutive days in a home setting, followed by the administration of four tablets of vaginal misoprostol (200mcg). Results: The results indicate that 70.4% of the studied women in Group A experienced complete abortion, whereas 63.6% of the studied women in Group B achieved the same outcome. Group A had a reduced length from induction to abortion in contrast to Group B, as well as a lower requirement for curettage when compared to Group B (6.8% against 9.1%, respectively). Conclusion: letrozole pretreatment with misoprostol increase the effectiveness of misoprostol without increase side effects. | ||||
| Keywords | ||||
| letrozole; Misoprostol; missed abortion &lrm | ||||
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