The Efficacy of Topical Sesame Oil in Orabase Versus Topical Triamcinolone in Orabase on Oral Lichen Planus and Salivary Level Of Oxidative Stress Biomarker (MDA): Randomized Clinical Trial
Mohammed, M., Azab, N., Shaker, O., Hussine, A. (2023). The Efficacy of Topical Sesame Oil in Orabase Versus Topical Triamcinolone in Orabase on Oral Lichen Planus and Salivary Level Of Oxidative Stress Biomarker (MDA): Randomized Clinical Trial. EKB Journal Management System, 5(4), 901-915. doi: 10.21608/adjc.2023.216208.1336
Mona Taha Mohammed; Noha Adel Azab; Olfat Gamil Shaker; Amal Ali Hussine. "The Efficacy of Topical Sesame Oil in Orabase Versus Topical Triamcinolone in Orabase on Oral Lichen Planus and Salivary Level Of Oxidative Stress Biomarker (MDA): Randomized Clinical Trial". EKB Journal Management System, 5, 4, 2023, 901-915. doi: 10.21608/adjc.2023.216208.1336
Mohammed, M., Azab, N., Shaker, O., Hussine, A. (2023). 'The Efficacy of Topical Sesame Oil in Orabase Versus Topical Triamcinolone in Orabase on Oral Lichen Planus and Salivary Level Of Oxidative Stress Biomarker (MDA): Randomized Clinical Trial', EKB Journal Management System, 5(4), pp. 901-915. doi: 10.21608/adjc.2023.216208.1336
Mohammed, M., Azab, N., Shaker, O., Hussine, A. The Efficacy of Topical Sesame Oil in Orabase Versus Topical Triamcinolone in Orabase on Oral Lichen Planus and Salivary Level Of Oxidative Stress Biomarker (MDA): Randomized Clinical Trial. EKB Journal Management System, 2023; 5(4): 901-915. doi: 10.21608/adjc.2023.216208.1336

The Efficacy of Topical Sesame Oil in Orabase Versus Topical Triamcinolone in Orabase on Oral Lichen Planus and Salivary Level Of Oxidative Stress Biomarker (MDA): Randomized Clinical Trial

Advanced Dental Journal
Volume 5, Issue 4, October 2023, Page 901-915  XML PDF (515.16 K)
Document Type: Original Article
DOI: 10.21608/adjc.2023.216208.1336
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Authors
Mona Taha Mohammed email 1; Noha Adel Azab1; Olfat Gamil Shaker2; Amal Ali Hussine1
1Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Egypt.
2Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Egypt.
Abstract
Objectives: To compare the efficacy of topical sesame oil in the formulation of gel and topical triamcinolone acetonide 0.1% in managing the signs and symptoms of OLP. Patients and Methods: This randomized, non-blind, controlled trial had thirty four patients who were randomized into two groups to receive either sesame oil oral gel or triamcinolone acetonide 0.1% oral gel thrice daily for 4 weeks.  The patients were analyzed for the symptom (burning) using visual analogue scale and sign (erythema and ulceration) using the thongprasome index and salivary MDA by ELISA technique.  Results: The VAS scores was statistically significant between both groups (p =0.003). The Thongprasome index was statistically significant between both groups (p< 0.001); The MDA was statistically insignificant between both groups (p= 0.838). Our analyses demonstrated statistically.  Conclusion:  Sesame oil has no detectable effect on improving the clinical picture of OLP. It had an inferior effect to triamcinolone in relieving pain and clinical picture.
Keywords
Triamcinolone acetonide; sesame oil; Thongprasome; VAS
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