Comparing antibiotic susceptibility profiles of urinary tract infection isolates in a University Hospital in Burkina Faso: Community vs. hospital profiles
Andre, N., Odilon, K., Aimée, K., Ali, M., Boukary, K., Aoua, S., Ahmed, O., Yacouba, S., Jacques, Z., Armel, P., Sylvain, G., Abdoul-Salam, O. (2024). Comparing antibiotic susceptibility profiles of urinary tract infection isolates in a University Hospital in Burkina Faso: Community vs. hospital profiles. EKB Journal Management System, 5(1), 314-323. doi: 10.21608/mid.2023.228523.1587
NAGALO Andre; KABORE Dieudonné Odilon; Kissou Senkaye-Lagom Aimée; Mahamoud Issaka Ali; KABRE Boukary; Semde Aoua; Ouattara Cheick Ahmed; Sawadogo Yacouba; ZOUNGRANA Jacques; Poda Armel; Godreuil Sylvain; Ouedraogo Abdoul-Salam. "Comparing antibiotic susceptibility profiles of urinary tract infection isolates in a University Hospital in Burkina Faso: Community vs. hospital profiles". EKB Journal Management System, 5, 1, 2024, 314-323. doi: 10.21608/mid.2023.228523.1587
Andre, N., Odilon, K., Aimée, K., Ali, M., Boukary, K., Aoua, S., Ahmed, O., Yacouba, S., Jacques, Z., Armel, P., Sylvain, G., Abdoul-Salam, O. (2024). 'Comparing antibiotic susceptibility profiles of urinary tract infection isolates in a University Hospital in Burkina Faso: Community vs. hospital profiles', EKB Journal Management System, 5(1), pp. 314-323. doi: 10.21608/mid.2023.228523.1587
Andre, N., Odilon, K., Aimée, K., Ali, M., Boukary, K., Aoua, S., Ahmed, O., Yacouba, S., Jacques, Z., Armel, P., Sylvain, G., Abdoul-Salam, O. Comparing antibiotic susceptibility profiles of urinary tract infection isolates in a University Hospital in Burkina Faso: Community vs. hospital profiles. EKB Journal Management System, 2024; 5(1): 314-323. doi: 10.21608/mid.2023.228523.1587

Comparing antibiotic susceptibility profiles of urinary tract infection isolates in a University Hospital in Burkina Faso: Community vs. hospital profiles

Microbes and Infectious Diseases
Article 33, Volume 5, Issue 1, February 2024, Page 314-323  XML PDF (791.83 K)
Document Type: Original Article
DOI: 10.21608/mid.2023.228523.1587
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Authors
NAGALO Andre email orcid 1, 2, 3; KABORE Dieudonné Odilonorcid 1, 4; Kissou Senkaye-Lagom Aiméeorcid 5, 4; Mahamoud Issaka Ali6; KABRE Boukary7; Semde Aoua8, 4; Ouattara Cheick Ahmedorcid 9, 4; Sawadogo Yacoubaorcid 1; ZOUNGRANA Jacquesorcid 10, 4; Poda Armelorcid 10, 4; Godreuil Sylvainorcid 11, 12; Ouedraogo Abdoul-Salamorcid 1, 4
1Sourô Sanou University Hospital, Laboratory of Bacteriology-Virology, 01 BP 676, Bobo-Dioulasso, Burkina Faso
2Regional University Hospital of Ouahigouya, Laboratory of Biomedical Analysis, 01 BP 36, Ouahigouya, Burkina Faso
310- University of Montpellier, 163 rue Auguste Broussonnet 34090 Montpellier, France
4NAZI BONI University, 01 BP 1091, Bobo-Dioulasso, Burkina Faso
5Sourô Sanou University Hospital, Department of Pediatrics, 01 BP 676, Bobo-Dioulasso, Burkina Faso
6Adam Barak University of Abéché, 02 BP 1173, Abéché, Tchad
7Department of Urology-Andrology, Tenkodogo Regional Hospital Center, 01 BP 56, Tenkodogo, Burkina Faso
8Sourô Sanou University Hospital, Department of Nephrology-Hemodialysis, 01 BP 676, Bobo-Dioulasso, Burkina Faso
9Sourô Sanou University Hospital, Department of Information, Epidemiology, Research and Planning, 01 BP 676, Bobo-Dioulasso, Burkina Faso
10Sourô Sanou University Hospital, Department of Infectious Diseases, 01 BP 676, Bobo-Dioulasso, Burkina Faso
11Arnaud de Villeneuse University Hospital, Bacteriology Laboratory, 34 295 Montpellier Cedex 5, France
12University of Montpellier, 163 rue Auguste Broussonnet 34090 Montpellier, France
Abstract
Background: The emergence of antimicrobial resistance (AMR) within bacterial pathogens necessitates a local comprehension of the epidemiological context. This information is indispensable for both clinical therapeutic determinations and the reevaluation of prevailing care protocols. This study aimed to highlight the antibiotic susceptibility profile of uropathogenic bacteria isolated within a university hospital in Burkina Faso, with a focus on enhancing probabilistic antibiotic therapy for both community and hospital-based urinary tract infections (UTIs). Methodology: Data from cytological urine analysis and antimicrobial susceptibility testing spanning 29 months (January 2017 to May 2019) was retrospectively collected and systematically analyzed. Results: In both hospital and community based UTIs, Enterobacterales dominated, constituting 79.86% (81.27% vs. 79.11%) of isolates. This was followed by non-fermentative Gram-negative bacteria at 6.60% (6.35% vs. 6.88%) and Gram-positive cocci at 6.41% (7.98% vs. 5.57%). Escherichia coli (61.37%), Klebsiella pneumoniae (10.66%), and Enterobacter spp. emerged as the predominant pathogens in the same rank regardless of the origin of the ITUs. Imipenem (97.19%), amikacin (69.26%), ceftriaxone (58.44%), and ciprofloxacin (47.60%) displayed superior susceptibility against all uropathogens. Subtle but significant variations emerged between hospital and community strains' susceptibility to various antibiotics, including amoxicillin + clavulanic acid (26.05% vs. 32.26%), Imipenem (96.43% vs. 98.59%), and ciprofloxacin (45.51% vs. 51.41%). Conclusion: Penicillins showcased diminished efficacy against uropathogens, while resistance to fluoroquinolones escalated. The combined use of aminoglycosides and third-generation cephalosporins holds promise as an optimal probabilistic therapy for UTIs. Notably, the profiles of hospital and community UTIs showed substantial similarities in terms of implicated uropathogens, yet hospital strains demonstrated higher resistance levels.
Keywords
antibiotics; resistance; uropathogens; Bobo-Dioulasso
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