Prevalence and clinical impact of neurocognitive symptoms in geriatric patients with COVID-19. | ||||
| The Egyptian Journal of Geriatrics and Gerontology | ||||
| Article 4, Volume 10, Issue 2, October 2023, Page 51-64 PDF (490.67 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejgg.2023.325913 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Mahmoud Mohamed Lotfy* ; Khalid Elsayed Elsorady; Samia Ahmed Abdul-Rahman; Mohamed Shawky khater | ||||
| Geriatrics and Gerontology Department, Faculty of Medicine, Ain Shams University. | ||||
| Abstract | ||||
| Background: Multiple neurocognitive manifestations of COVID-19 have been reported. Symptomatic patients with COVID-19 typically present with respiratory symptoms but neurocognitive symptoms are common, especially in geriatric hospitalized patients with severe infection. Objective: To determine the prevalence and clinical impact of neurocognitive symptoms on the outcome of COVID-19 in geriatric patients. Patients and methods: A retrospective observational study conducted in Ain-Shams University Geriatrics hospital for isolation of COVID-19 patients. Number of included patients was 233 patients with positive Reverse Transcription Polymerase Chain Reaction (RT-PCR) results for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) infection. Length of stay was determined and mortality was the primary clinical outcome. Statistical analyses were performed. Results: We found that 54% of the studied cases had neurocognitive manifestations. Delirium and decline in consciousness levels were higher in deceased patients with statistically significant differences. There was a significant difference between alive and deceased groups regarding the presence of either neurocognitive or respiratory symptoms. A higher Acute Physiology and Chronic Health Evaluation II (APACHE II) score was significantly associated with a higher mortality rate. There were significant differences regarding TLC, serum sodium, Blood Urea Nitrogen (BUN), creatinine, albumin, C - C-reactive protein (CRP), Ferritin, and D-Dimer. Upon regression analysis, a higher APACHE II score was an independent risk factor for mortality. Conclusion: Neurocognitive manifestations were common among hospitalized geriatric patients with COVID-19 and were associated with poor hospital outcomes. Accordingly, these manifestations should be taken seriously and should receive early interventions to prevent undesirable events. | ||||
| Keywords | ||||
| Neurocognitive symptoms; Delirium; COVID-19; Geriatric patients | ||||
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