Effect of Vitamin D Levels on Egyptian Children with Type-1 Diabetes Mellitus
Ibrahim, H., Elsayed, M., Hindy, O., Agroudy, A., Kelany, A. (2024). Effect of Vitamin D Levels on Egyptian Children with Type-1 Diabetes Mellitus. EKB Journal Management System, 5(1), 83-89. doi: 10.21608/ajbas.2023.230822.1174
Hamdy Abo elhaded Ibrahim; Mohamed Ramadan Elsayed; Odette Wahba Hindy; Ayman El baz Agroudy; Ayda kamal Kelany. "Effect of Vitamin D Levels on Egyptian Children with Type-1 Diabetes Mellitus". EKB Journal Management System, 5, 1, 2024, 83-89. doi: 10.21608/ajbas.2023.230822.1174
Ibrahim, H., Elsayed, M., Hindy, O., Agroudy, A., Kelany, A. (2024). 'Effect of Vitamin D Levels on Egyptian Children with Type-1 Diabetes Mellitus', EKB Journal Management System, 5(1), pp. 83-89. doi: 10.21608/ajbas.2023.230822.1174
Ibrahim, H., Elsayed, M., Hindy, O., Agroudy, A., Kelany, A. Effect of Vitamin D Levels on Egyptian Children with Type-1 Diabetes Mellitus. EKB Journal Management System, 2024; 5(1): 83-89. doi: 10.21608/ajbas.2023.230822.1174

Effect of Vitamin D Levels on Egyptian Children with Type-1 Diabetes Mellitus

Alfarama Journal of Basic & Applied Sciences
Volume 5, Issue 1, January 2024, Page 83-89  XML PDF (671.45 K)
Document Type: Review Article
DOI: 10.21608/ajbas.2023.230822.1174
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Authors
Hamdy Abo elhaded Ibrahim email 1; Mohamed Ramadan Elsayed2; Odette Wahba Hindy3; Ayman El baz Agroudy4; Ayda kamal Kelany5
1Chemistry , Faculty of Science ,. Port Said University , Port Said , Egypt .
2Chemistry , Faculty of Science , Port Said University , Port Said , Egypt
3Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt
4Department of Basic Medical Sciences, Faculty of Medicine, University of Ibn Sina for Medical Sciences, Amman, Jordan
5Department of Genomic Medicine, Cairo University hospitals, Cairo University, Cairo, Egypt
Abstract
Background: There are some explanations for the relationship between vitamin D (Vit. D) low levels and type 1 diabetes mellitus (T1DM). T1DM is an autoimmune disorder that affects pancreatic cells, Vit. D acts an immunomodulatory function via the Vit. D receptor abundant on immune and pancreatic cells. By lowering the number of effector "T" cells, it has been demonstrated that great concentrations of 1,25-dihydroxyvitamin D positively lower the diabetes' occurrence. Our study's aimed to assess the potential role of Vit. D concentration in early infancy as an indicator of possibly developing islet autoimmunity or clinical T1DM. Method: This was a case-control study involving 40 T1DM-diagnosed children aged 6 to 12 years and 20 healthy children as controls with comparable gender, height (cm), age, weight (Kg), and body mass index (BMI). For all subjects, serum hydroxyl Vit. D (25 OHD) was measured using chemiluminescence immunoassay. Serum total Ca, ph, ALP and PTH were measured. Also, HbA1C% was measured win both groups, and blood glucose was also measured. Mg, AST and ALT were also assessed. Results: The mean serum 25OHD in T1DM children was less than Healthy controls 9.3+1.4Vs 59.2+18.7ng/ml respectively with (p < 0.0001) and diabetic cases showed negatively significant relationship between vitamin D versus HbA1c% and glucose, (r = -0.8, -0.9) respectively (p < 0.0001). Conclusion: Vitamin D deficiency is frequent in children with T1DM, and it is important to pay attention to this issue. Future studies will be interested in investigating vitamin D supplementation for autoimmune diseases, particularly T1DM.
Keywords
Vitamin D; T1DM; PTH and HbA1C
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