Neutrophils as a cellular marker of inflammation among adult patients with pulmonary tuberculosis in Zaria, Nigeria | ||||
International Journal of Health Sciences (Egypt) | ||||
Article 2, Volume 2, Issue 1, January 2024, Page 12-18 PDF (785.48 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ijhegy.2023.247679.1039 | ||||
View on SCiNiTO | ||||
Authors | ||||
Mairiga Saad 1; Abdallahi Abba2; Bolanle Olufunke Priscilla Musa3; Abdurrahman El-fulaty Ahmad4; Musa Muhammad5 | ||||
1Ahmadu Bello University Zaria | ||||
2Pulmunonology Unit, Department of Medicine, Ahmadu Bello University, Zaria – Nigeria | ||||
3Immunology Unit, Department of Medicine, Ahmadu Bello University, Zaria – Nigeria | ||||
4Department of Medical Laboratory Science, Ahmadu Bello University, Zaria - Nigeria | ||||
5Ahmad1,3, Musa Mohammed1 Immunology Unit, Department of Medicine, Ahmadu Bello University, Zaria – Nigeria | ||||
Abstract | ||||
Background: Tuberculosis (TB) remains a significant cause of morbidity and mortality worldwide. Complications of the disease is associated with the host’s inflammatory response. The study aimed to determine percentage neutrophil as a cellular biomarker of inflammation among adult patients with pulmonary tuberculosis in Zaria. Methods: This was a cross sectional study. Blood samples were taken from 30 treatment-naïve (TN), 30 treatment-experienced (TE) and 30 healthy controls (HC) for percentage neutrophils count. Results: The mean values of percentage neutrophils count for TN, TE and HC were 65.8 ± 7.3, 46.0 ± 11.8 and 55.8 ± 8.3, respectively. There was a decrease in neutrophils counts of TE patients compared with HC, an increased in neutrophils counts of TN compared with HC and a significant difference between TE and TN (P<0.0001).Conclusion Percentage Neutrophils should be use as a cellular biomarker for the monitoring of treatment response among adult patients with pulmonary Tuberculosis. | ||||
Keywords | ||||
Neutrophil; Tuberculosis; Biomarker; Inflammation | ||||
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