Assessment of the Diagnostic Value of the Terminal Complement Complex, Factor D and factor H in Preeclampsia
Assaf, D., Deaf, E., Elgendy, S., Abbas, A., Shaltout, A. (2024). Assessment of the Diagnostic Value of the Terminal Complement Complex, Factor D and factor H in Preeclampsia. EKB Journal Management System, 33(1), 49-56. doi: 10.21608/ejmm.2024.326879
Dina M. Assaf; Enas A. Deaf; Shereine GG. Elgendy; Ahmed M. Abbas; Asmaa S. Shaltout. "Assessment of the Diagnostic Value of the Terminal Complement Complex, Factor D and factor H in Preeclampsia". EKB Journal Management System, 33, 1, 2024, 49-56. doi: 10.21608/ejmm.2024.326879
Assaf, D., Deaf, E., Elgendy, S., Abbas, A., Shaltout, A. (2024). 'Assessment of the Diagnostic Value of the Terminal Complement Complex, Factor D and factor H in Preeclampsia', EKB Journal Management System, 33(1), pp. 49-56. doi: 10.21608/ejmm.2024.326879
Assaf, D., Deaf, E., Elgendy, S., Abbas, A., Shaltout, A. Assessment of the Diagnostic Value of the Terminal Complement Complex, Factor D and factor H in Preeclampsia. EKB Journal Management System, 2024; 33(1): 49-56. doi: 10.21608/ejmm.2024.326879

Assessment of the Diagnostic Value of the Terminal Complement Complex, Factor D and factor H in Preeclampsia

Egyptian Journal of Medical Microbiology
Volume 33, Issue 1, January 2024, Page 49-56  XML PDF (329.42 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2024.326879
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Authors
Dina M. Assaf1; Enas A. Deaf2; Shereine GG. Elgendy2; Ahmed M. Abbas3; Asmaa S. Shaltout email 2
1Microbiology and Immunology Department, Faculty of Pharmacy, Assiut University, Assiut
2Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut
3Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut
Abstract
Background: To assess the diagnostic role of serum complement factor H (CFH), complement factor D (CFD), and terminal complement complex (C5b-9) and urine C5b-9 in women diagnosed with preeclampsia (PE) and severe PE compared to normal pregnancy. Methodology: A cross-sectional study involved 89 women divided into three groups: Group I, thirty women with PE, and Group II, thirty women with severe PE. Group III consisted of twenty-nine women with normal pregnancies as a control group. Estimation of serum levels of CFH, CFD, C5b-9, and urine C5b-9 levels in different study groups was done by ELISA test. A correlation analysis was carried out between levels of complement factors, clinical data, and laboratory tests. Results: Serum CFD, CFH, C5b-9, and urine C5b-9 levels were significantly elevated in patients with PE and severe PE compared to a normal pregnancy (p <0.001). In addition, severe PE patients showed a significant increase compared to the PE group (p <0.001). A significant positive correlation was found between serum CFD, CFH, C5b-9, and urine C5b-9 with both systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patient groups. The accuracy of serum CFH, C5b-9, and urine C5b-9 in the diagnosis of severe PE was found to be 100%, while serum CFD had an overall accuracy of 98.9%. Conclusion: Serum CFH, CFD, C5b-9, and urine C5b-9 can serve as diagnostic markers for severe PE, aiding in early detection of high-risk patients, disease monitoring, and appropriate treatment.
Keywords
Preeclampsia; Complement; High risk pregnancy; Hypertension
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