Study on the Impact of metabolic associated fatty liver disease (MAFLD) on patients with Corona Virus Disease – 2019 (COVID-19)
Oraby, M., Mazoun, M., Mohamed, A., Fawzy, M., Abdel-Aziz, T., Dahshan, I. (2023). Study on the Impact of metabolic associated fatty liver disease (MAFLD) on patients with Corona Virus Disease – 2019 (COVID-19). EKB Journal Management System, 40(3), 817-827. doi: 10.21608/bmfj.2023.242125.1924
Mahmoud Oraby; Mahmoud Mazoun; Ahmed Qassem Mohamed; Mai Fawzy; Taher Abdel-Aziz; Ismail Dahshan. "Study on the Impact of metabolic associated fatty liver disease (MAFLD) on patients with Corona Virus Disease – 2019 (COVID-19)". EKB Journal Management System, 40, 3, 2023, 817-827. doi: 10.21608/bmfj.2023.242125.1924
Oraby, M., Mazoun, M., Mohamed, A., Fawzy, M., Abdel-Aziz, T., Dahshan, I. (2023). 'Study on the Impact of metabolic associated fatty liver disease (MAFLD) on patients with Corona Virus Disease – 2019 (COVID-19)', EKB Journal Management System, 40(3), pp. 817-827. doi: 10.21608/bmfj.2023.242125.1924
Oraby, M., Mazoun, M., Mohamed, A., Fawzy, M., Abdel-Aziz, T., Dahshan, I. Study on the Impact of metabolic associated fatty liver disease (MAFLD) on patients with Corona Virus Disease – 2019 (COVID-19). EKB Journal Management System, 2023; 40(3): 817-827. doi: 10.21608/bmfj.2023.242125.1924

Study on the Impact of metabolic associated fatty liver disease (MAFLD) on patients with Corona Virus Disease – 2019 (COVID-19)

Benha Medical Journal
Article 20, Volume 40, Issue 3, November and December 2023, Page 817-827  XML PDF (728 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2023.242125.1924
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Authors
Mahmoud Oraby1; Mahmoud Mazoun1; Ahmed Qassem Mohamed2; Mai Fawzy3; Taher Abdel-Aziz email 4; Ismail Dahshan5
1Hepatology, Gastroenterology and Infectious Diseases Department, Toukh Fever Hospital, Qalyubia Directorate of Health, Ministry of Health and Population, Egypt
2Department of Hepatogastroentrology and Infectious Diseases, Al-Azhar University, Egypt
3Radiology Department, Benha Fever Hospital, Qalyubia Directorate of Health, Ministry of Health and Population, Egypt
4Clinical Research Unit, Directorate of Health Affairs in Qalyubia, Ministry of Health and Population, Egypt
5Department of Family Medicine, Faculty of Medicine, Sues Canal University, Egypt
Abstract
Purpose: This study aimed to assess the impact of metabolic (dysfunction) associated fatty liver disease (MAFLD) on the outcome of patients with COVID-19.
Patients and Methods: This prospective observational study assessed the impact of MAFLD on COVID-19 outcomes in patients treated at Toukh Fever Hospital from January 2022 to February 2023. The study involved adult patients with confirmed COVID-19, excluding those with specific liver-related conditions, and included comprehensive clinical, laboratory, and ultrasonographic assessments. The severity of COVID-19 was evaluated according to the Egyptian protocol, and the diagnosis of MAFLD followed international consensus criteria.
Results: Patients with MAFLD had a higher BMI, a greater prevalence of hypertension and type 2 diabetes, and exhibited unique laboratory findings, including lower hemoglobin and lymphocyte counts, elevated inflammatory markers, and dyslipidemia. The severity of COVID-19 and mortality rates were significantly elevated in patients with MAFLD.
Conclusion: Patients with MAFLD exhibited distinct clinical and laboratory features and were at risk of developing severe COVID-19 and worse outcomes.
Keywords
COVID-19; metabolic associated fatty liver disease (MAFLD); outcome
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