REMINERALIZATION OF SELF-ASSEMBLING PEPTIDE P11-4 AND CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE FLUORIDE ON CARIES-LIKE LESIONS IN PRIMARY TEETH (IN-VITRO STUDY)
Habashy, P., Dowidar, K., Abdel Fattah, H., Sharaf, D. (2023). REMINERALIZATION OF SELF-ASSEMBLING PEPTIDE P11-4 AND CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE FLUORIDE ON CARIES-LIKE LESIONS IN PRIMARY TEETH (IN-VITRO STUDY). EKB Journal Management System, 48(3), 210-216. doi: 10.21608/adjalexu.2023.246496.1432
Peter G Habashy; Karin M L Dowidar; hager S Abdel Fattah; Dina A Sharaf. "REMINERALIZATION OF SELF-ASSEMBLING PEPTIDE P11-4 AND CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE FLUORIDE ON CARIES-LIKE LESIONS IN PRIMARY TEETH (IN-VITRO STUDY)". EKB Journal Management System, 48, 3, 2023, 210-216. doi: 10.21608/adjalexu.2023.246496.1432
Habashy, P., Dowidar, K., Abdel Fattah, H., Sharaf, D. (2023). 'REMINERALIZATION OF SELF-ASSEMBLING PEPTIDE P11-4 AND CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE FLUORIDE ON CARIES-LIKE LESIONS IN PRIMARY TEETH (IN-VITRO STUDY)', EKB Journal Management System, 48(3), pp. 210-216. doi: 10.21608/adjalexu.2023.246496.1432
Habashy, P., Dowidar, K., Abdel Fattah, H., Sharaf, D. REMINERALIZATION OF SELF-ASSEMBLING PEPTIDE P11-4 AND CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE FLUORIDE ON CARIES-LIKE LESIONS IN PRIMARY TEETH (IN-VITRO STUDY). EKB Journal Management System, 2023; 48(3): 210-216. doi: 10.21608/adjalexu.2023.246496.1432

REMINERALIZATION OF SELF-ASSEMBLING PEPTIDE P11-4 AND CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE FLUORIDE ON CARIES-LIKE LESIONS IN PRIMARY TEETH (IN-VITRO STUDY)

Alexandria Dental Journal
Article 4, Volume 48, Issue 3, December 2023, Page 210-216  XML PDF (367.9 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2023.246496.1432
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Authors
Peter G Habashy email orcid 1; Karin M L Dowidarorcid 2; hager S Abdel Fattahorcid 3; Dina A Sharaforcid 4
1Instructor of Pediatric Dentistry, Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
2Professor of Pediatric Dentistry, Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
3Lecturer of Oral Biology, Oral Biology Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
4Lecturer of Pediatric Dentistry, Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Abstract
Introduction: The early stages of dental caries involve enamel demineralization which can be reversed. Attempts have been made to develop new materials to remineralize enamel.
Objectives: To assess remineralizing effect of self-assembling peptide P11-4 and casein phosphopeptide-amorphous calcium phosphate fluoride(CPP-ACPF) in comparison to sodium fluoride varnish on early carious lesions in primary teeth.
Materials and methods: Thirty-six sound-extracted primary anterior teeth were used. A 4x4mm window was made in the middle of the labial surface of each tooth. Teeth were subjected to artificial demineralization and then randomly allocated into 3 groups: Group I(5%NaF varnish), Group II(CPP-ACPF varnish) and Group III(self-assembling peptide P11-4). Teeth were sectioned longitudinally into two halves. One half was treated by the remineralizing agent, and the other was left untreated as a negative control. Samples were subjected to elemental analysis to evaluate the changes in Ca and P content using Energy Dispersive X-ray spectrometer(EDX) and to assess the surface topography by Scanning-Electron-Microscope(SEM).
Results: There was a significant difference in the mineral content within each group before and after treatment indicating remineralization in all groups. The percent increase in Ca/P ratio after treatment was higher in self-assembling peptide P11-4 group than other groups with no significant difference between groups. Surface topography showed improvement in all groups with better surface quality in self-assembling peptide P11-4 group than other groups.
Conclusion: The CPP-ACPF varnish, Self-assembling peptide P11-4 and 5% Sodium fluoride varnish are effective in restoring the mineral content and improving surface morphology of early carious lesions in primary teeth.
Keywords
Self-assembling peptide P11-4; casein phosphopeptide; amorphous calcium phosphate; Sodium Fluoride
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