IN-SILICO STUDY OF CASSIA TORA LINN IN THE TREATMENT OF GAUCHER DISEASE: A SCIENTIFIC ETHNOMEDICAL STUDY
DSNBK, P., Bhavanam, P., Pasala, P., Panda, S., Achanti, S., Jash, R., Namratha, J., Sai Kiran, B., Sandeep, K., Ayesha, M., Mokkapati, P., Chaganti, P. (2023). IN-SILICO STUDY OF CASSIA TORA LINN IN THE TREATMENT OF GAUCHER DISEASE: A SCIENTIFIC ETHNOMEDICAL STUDY. EKB Journal Management System, 46(2), 803-815. doi: 10.21608/bfsa.2023.327332
Prasanth DSNBK; Pamula Reddy Bhavanam; Praveen Kumar Pasala; Siva Prasad Panda; Suneetha Achanti; Rajiv Jash; Jamullamudi Risy Namratha; Badithala Siva Sai Kiran; Katneni Sandeep; Md. Beebi Ayesha; Poojitha Mokkapati; Pavithra Chaganti. "IN-SILICO STUDY OF CASSIA TORA LINN IN THE TREATMENT OF GAUCHER DISEASE: A SCIENTIFIC ETHNOMEDICAL STUDY". EKB Journal Management System, 46, 2, 2023, 803-815. doi: 10.21608/bfsa.2023.327332
DSNBK, P., Bhavanam, P., Pasala, P., Panda, S., Achanti, S., Jash, R., Namratha, J., Sai Kiran, B., Sandeep, K., Ayesha, M., Mokkapati, P., Chaganti, P. (2023). 'IN-SILICO STUDY OF CASSIA TORA LINN IN THE TREATMENT OF GAUCHER DISEASE: A SCIENTIFIC ETHNOMEDICAL STUDY', EKB Journal Management System, 46(2), pp. 803-815. doi: 10.21608/bfsa.2023.327332
DSNBK, P., Bhavanam, P., Pasala, P., Panda, S., Achanti, S., Jash, R., Namratha, J., Sai Kiran, B., Sandeep, K., Ayesha, M., Mokkapati, P., Chaganti, P. IN-SILICO STUDY OF CASSIA TORA LINN IN THE TREATMENT OF GAUCHER DISEASE: A SCIENTIFIC ETHNOMEDICAL STUDY. EKB Journal Management System, 2023; 46(2): 803-815. doi: 10.21608/bfsa.2023.327332

IN-SILICO STUDY OF CASSIA TORA LINN IN THE TREATMENT OF GAUCHER DISEASE: A SCIENTIFIC ETHNOMEDICAL STUDY

Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 2, December 2023, Page 803-815  XML PDF (1.39 MB)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.327332
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Authors
Prasanth DSNBK email orcid 1; Pamula Reddy Bhavanam2; Praveen Kumar Pasala3; Siva Prasad Panda4; Suneetha Achanti5; Rajiv Jash6; Jamullamudi Risy Namratha7; Badithala Siva Sai Kiran8; Katneni Sandeep9; Md. Beebi Ayesha9; Poojitha Mokkapati9; Pavithra Chaganti9
1Department of Pharmacognosy, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada – 520010, Andhra Pradesh, India.
2Department of Pharmaceutics, Nirmala College of Pharmacy, Atmakuru, AP 522503, India
3Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu 515721, Andhra Pradesh, India
4Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, UP, India
5Department of Pharmaceutical Analysis, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, AP, 520010, India
6Department of Pharmacology, Sanaka Educational Trusts group of Institution, Malandighi, Durgapur, West Bengal, India
7Department of Pharmaceutical Chemistry, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Green Fields, Vaddeswaram, Guntur (Dt), Andhra Pradesh, India
8Department of Pharmaceutical Sciences, Vignan Pharmacy College, Vadlamudi, Andhra Pradesh 522213, India
9Department of Pharmacognosy, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, AP, 520010, India
Abstract
The field of pharmacognosy and herbal medicine has been growing steadily over the years due to the increasing number of studies on the side effects of modern medicines and the development of new drug lines. Plants possess therapeutic properties. Gaucher disease is a rare disorder caused by a defective GBA1 gene, which encodes the acid-β-glucosidase enzyme. The molecular docking technique revealed good binding efficiency of the selected bioactive compounds from Cassia tora (C. tora) against the acid-β-glucosidase enzyme that causes GD. A computational approach was used to analyze the ADMET profiles of various phytocompounds using admetsar, protox-ii, and swissadme software. ADMET analysis revealed that Obtusifolin-2-glucoside and Cassiaside had good Health Impact Assessment  (HIA) and showed no toxic effects. Preventive measures for GD result in side effects that are inaccessible and  result in the emergence of phytocompounds with fewer toxic effects. The obtusifolin-2-glucoside and Cassiaside of C. tora exhibited good docking scores of -7.2 and -7 kcal/mol, respectively,  and could be further analyzed using molecular dynamics and in vitro studies.
Keywords
Obtusifolin-2-glucoside; Cassia tora Linn; Gaucher Disease; Acid-β-glucosidases; In-silico; ADMET
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