PHARMACOGNOSTIC, PHYTOCHEMICAL EVALUATION, AND ANTIOXIDANT ACTIVITY OF THE LEAVES OF GREWIA BILAMELLATA GAGNEP. (TILIACEAE)
Gurivelli, P., Katta, S. (2023). PHARMACOGNOSTIC, PHYTOCHEMICAL EVALUATION, AND ANTIOXIDANT ACTIVITY OF THE LEAVES OF GREWIA BILAMELLATA GAGNEP. (TILIACEAE). EKB Journal Management System, 46(2), 817-833. doi: 10.21608/bfsa.2023.327333
Poornima Gurivelli; Sunitha Katta. "PHARMACOGNOSTIC, PHYTOCHEMICAL EVALUATION, AND ANTIOXIDANT ACTIVITY OF THE LEAVES OF GREWIA BILAMELLATA GAGNEP. (TILIACEAE)". EKB Journal Management System, 46, 2, 2023, 817-833. doi: 10.21608/bfsa.2023.327333
Gurivelli, P., Katta, S. (2023). 'PHARMACOGNOSTIC, PHYTOCHEMICAL EVALUATION, AND ANTIOXIDANT ACTIVITY OF THE LEAVES OF GREWIA BILAMELLATA GAGNEP. (TILIACEAE)', EKB Journal Management System, 46(2), pp. 817-833. doi: 10.21608/bfsa.2023.327333
Gurivelli, P., Katta, S. PHARMACOGNOSTIC, PHYTOCHEMICAL EVALUATION, AND ANTIOXIDANT ACTIVITY OF THE LEAVES OF GREWIA BILAMELLATA GAGNEP. (TILIACEAE). EKB Journal Management System, 2023; 46(2): 817-833. doi: 10.21608/bfsa.2023.327333

PHARMACOGNOSTIC, PHYTOCHEMICAL EVALUATION, AND ANTIOXIDANT ACTIVITY OF THE LEAVES OF GREWIA BILAMELLATA GAGNEP. (TILIACEAE)

Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 2, December 2023, Page 817-833  XML PDF (1.88 MB)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.327333
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Authors
Poornima Gurivelli1; Sunitha Katta email 2
1Research Scholar, Department of Pharmacognosy, Gitam School of pharmacy, Gitam University, Visakhapatnam, Andhra Pradesh, India
2Department of Pharmacognosy, Gitam School of pharmacy, Gitam University, visakhapatnam. Andhra Pradesh, India
Abstract
This research seeks to analyze the Pharmacognostic, Phytochemical evaluation, Total Phenolic, Flavonoid Content, and Antioxidant activity of the leaves of Grewia bilamellata Gagnep. (G. bilamellata). This Pharmacognostic study comprises microscopic observation, leaf characteristics, phytochemical and physicochemical analyses, and total phenolic and flavonoid content. Antioxidant activity was examined using  1,1-diphenyl-2-picrylhydrazyl (DPPH) and H2O2  assays. The leaf shows anomocytic stomata, covering, glandular and stellate type of trichomes, Total phenolic and flavonoid content turned greatest in ethanolic extract (EEGB) (90.69±2.86 mg GAE/g), and (26.21 ± 1.51 mg RE/g), respectively. EEGB showed the most intense 1,1-diphenyl-2-picrylhydrazyl (DPPH) and H2O2 scavenging activity, with  IC50 59.96 and  59.24 µg/ml. Total phenolic and flavonoid contents - DPPH and H2O2 scavenging assays were positively correlated. The Invitro Antioxidant results were also correlated with the Insilico method using xanthine oxidase (XOD) and superoxide dismutase (SOD) as targets. Microscopic and physicochemical parameters are valuable for authenticating drug identification and purity. G. bilamellata is a potential perspective source of antioxidants.
Keywords
Grewia bilamellata Gagnep; Antioxidant; Pharmacognostic; Insilico
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