EFFORTS IN IMPROVING TABLETS’ TENSILE STRENGTH WITH A COATING SYSTEM AND BRITTLE EXCIPIENT: A REVIEW
Ainurofiq, A., Wuslatush Sholekah, C., Hanifah, D., Susanti, E., Suryaningrum, M., Kusumawardhani, M. (2023). EFFORTS IN IMPROVING TABLETS’ TENSILE STRENGTH WITH A COATING SYSTEM AND BRITTLE EXCIPIENT: A REVIEW. EKB Journal Management System, 46(2), 669-682. doi: 10.21608/bfsa.2023.327335
Ahmad Ainurofiq; Chalimatussa’diyah Wuslatush Sholekah; Dzakiyyatul Hanifah; Eka Nurulita Susanti; Meila Tunjung Suryaningrum; Meyliana Adhitya Kusumawardhani. "EFFORTS IN IMPROVING TABLETS’ TENSILE STRENGTH WITH A COATING SYSTEM AND BRITTLE EXCIPIENT: A REVIEW". EKB Journal Management System, 46, 2, 2023, 669-682. doi: 10.21608/bfsa.2023.327335
Ainurofiq, A., Wuslatush Sholekah, C., Hanifah, D., Susanti, E., Suryaningrum, M., Kusumawardhani, M. (2023). 'EFFORTS IN IMPROVING TABLETS’ TENSILE STRENGTH WITH A COATING SYSTEM AND BRITTLE EXCIPIENT: A REVIEW', EKB Journal Management System, 46(2), pp. 669-682. doi: 10.21608/bfsa.2023.327335
Ainurofiq, A., Wuslatush Sholekah, C., Hanifah, D., Susanti, E., Suryaningrum, M., Kusumawardhani, M. EFFORTS IN IMPROVING TABLETS’ TENSILE STRENGTH WITH A COATING SYSTEM AND BRITTLE EXCIPIENT: A REVIEW. EKB Journal Management System, 2023; 46(2): 669-682. doi: 10.21608/bfsa.2023.327335

EFFORTS IN IMPROVING TABLETS’ TENSILE STRENGTH WITH A COATING SYSTEM AND BRITTLE EXCIPIENT: A REVIEW

Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 2, December 2023, Page 669-682  XML PDF (1.21 MB)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.327335
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Authors
Ahmad Ainurofiq email orcid ; Chalimatussa’diyah Wuslatush Sholekah; Dzakiyyatul Hanifah; Eka Nurulita Susanti; Meila Tunjung Suryaningrum; Meyliana Adhitya Kusumawardhani
Department of Pharmacy, Sebelas Maret University, Ir. Sutami 36A, Surakarta 57126, Indonesia
Abstract
Tablets are the most in-demand pharmaceutical preparation by pharmaceutical companies or users because they provide the best capabilities from all oral preparations. Maintaining the grade and quality of tablets need to be of great concern. Factors affecting the physical quality of tablets must always be evaluated, including tensile strength. Tensile strength directly affects the process of distribution, storage, disintegration, and dissolution of tablets. Tensile strength problem is often found during tablet production with the wet granulation method, in which over-granulation often occurs, especially in high-shear wet granulation (HSWG). The solution for over granulating is the addition of brittle excipients to form a strong bond when combined, thus increasing tensile strength. An ideal tensile strength may be achieved because the mechanical strength of the tablet is increased proportionally to the increased area of the bond. Another solution to increase tensile strength is by using a coating system using the Multiple Unit Pellet Systems (MUPS). The MUPS coating system often experiences problems such as caking. This problem can be overcome using a coating polymer that is stable on high RH and supports a strong tablet formulation. The solution to the tensile strength problem with the addition of brittle excipients and coating will be reviewed in this article to increase tensile strength
Keywords
Tablet; wet granulation; tensile strength; brittle excipient; coating system
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