AMELIORATED EFFECT OF COMBINED TREATMENT OF BLUEBERRY FRUIT EXTRACT AND VOGLIBOSE ON STREPTOZOTOCIN-INDUCED TYPE Ⅱ DIABETES MELLITUS IN RATS
Baheg, O., Aboutabl, M., El Sayed, N., Maklad, Y., Kenawy, S. (2023). AMELIORATED EFFECT OF COMBINED TREATMENT OF BLUEBERRY FRUIT EXTRACT AND VOGLIBOSE ON STREPTOZOTOCIN-INDUCED TYPE Ⅱ DIABETES MELLITUS IN RATS. EKB Journal Management System, 46(2), 1325-1339. doi: 10.21608/bfsa.2023.327540
Omnia E. Baheg; Mona E. Aboutabl; Nesrine S. El Sayed; Yousreya A. Maklad; Sanaa A. Kenawy. "AMELIORATED EFFECT OF COMBINED TREATMENT OF BLUEBERRY FRUIT EXTRACT AND VOGLIBOSE ON STREPTOZOTOCIN-INDUCED TYPE Ⅱ DIABETES MELLITUS IN RATS". EKB Journal Management System, 46, 2, 2023, 1325-1339. doi: 10.21608/bfsa.2023.327540
Baheg, O., Aboutabl, M., El Sayed, N., Maklad, Y., Kenawy, S. (2023). 'AMELIORATED EFFECT OF COMBINED TREATMENT OF BLUEBERRY FRUIT EXTRACT AND VOGLIBOSE ON STREPTOZOTOCIN-INDUCED TYPE Ⅱ DIABETES MELLITUS IN RATS', EKB Journal Management System, 46(2), pp. 1325-1339. doi: 10.21608/bfsa.2023.327540
Baheg, O., Aboutabl, M., El Sayed, N., Maklad, Y., Kenawy, S. AMELIORATED EFFECT OF COMBINED TREATMENT OF BLUEBERRY FRUIT EXTRACT AND VOGLIBOSE ON STREPTOZOTOCIN-INDUCED TYPE Ⅱ DIABETES MELLITUS IN RATS. EKB Journal Management System, 2023; 46(2): 1325-1339. doi: 10.21608/bfsa.2023.327540

AMELIORATED EFFECT OF COMBINED TREATMENT OF BLUEBERRY FRUIT EXTRACT AND VOGLIBOSE ON STREPTOZOTOCIN-INDUCED TYPE Ⅱ DIABETES MELLITUS IN RATS

Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 2, December 2023, Page 1325-1339  XML PDF (1.21 MB)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.327540
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Authors
Omnia E. Baheg email 1; Mona E. Aboutabl2; Nesrine S. El Sayed3; Yousreya A. Maklad2; Sanaa A. Kenawy3
1Medicinal and Pharmaceutical Chemistry Department, National Research Centre, 33–El Behouth St., 12622, Dokki, Giza, Egypt Pharmaceutical and Drug Industries Research Division, National Research Centre, 33–El Behouth St., 12622, Giza, Egypt
2Medicinal and Pharmaceutical Chemistry Department, National Research Centre, 33–El Behouth St., 12622, Dokki, Giza, Egypt
3Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Giza, Egypt
Abstract
Blueberries are rich in anthocyanins, which have been studied for many years. Interest in these compounds has grown attributing to their possible therapeutic and beneficial effects. Therefore, this study aimed to investigate the potential antioxidant, anti-inflammatory, hepatoprotective, anti-diabetic, and anti-inflammatory effects of blueberry fruit extract supplement (25% anthocyanin) in combination with aloglibtin and voglibose in streptozotocin (STZ)-induced diabetic rats.
Diabetes mellitus was induced in six groups with a single 45 mg/kg STZ injection. However, 5 of these groups were treated with alogliptin (Alog), voglibose (Vog), blueberry fruit extract (BB-fruit extract), combined treatment of (Alog + BB-fruit extract), and (Vog + BB-fruit extract), respectively, for three weeks. Serum glucose, C-peptide, lipid profile, liver enzymes, kidney enzymes, and TNF-α levels were estimated. Meanwhile, alpha-glucosidase, catalase, and superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels were determined in rats' liver tissues.
All diabetic groups unveiled a significant decrease in serum glucose and C-peptide level after administering BB-fruit extract. Combination of BB-fruit extract and vog is effective in achieving sufficient glycemic control by significantly reducing inflammation, oxidative stress, hyperlipidemia, and hyperglycemia. These findings imply that this combination is an effective strategy for controlling diabetes.
Keywords
Type Ⅱ diabetes; Vaccinium uliginosum L; Berries; Liver; Antioxidant
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