THE POTENTIAL PROTECTIVE EFFECT OF STEVIA REBAUDIANA ON DEXAMETHASONE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS: ROLE OF PPAR- | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Volume 46, Issue 2, December 2023, Page 1341-1359 PDF (1.46 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.2023.327568 | ||||
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Authors | ||||
Mohamed M. Elbadr1; Eman Mohamed 2; Hoda M. Elsayed3; Mahran S. Abdel-Rahman1 | ||||
1Department of Medical Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt Department of Pharmacology and Toxicology, College of Pharmacy, Sphinx University, New Assiut City, Assiut, Egypt | ||||
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sohag University,Sohag, Egypt. | ||||
3Department of Histology and Cell biology, Faculty of Medicine, Sohag University, Sohag, Egypt | ||||
Abstract | ||||
Background: Currently, using medicinal herbs has a great interest in the treatment of nonalcoholic fatty liver disease (NAFLD). This study evaluated the impact of stevia on the hallmark signs of dexamethasone-induced NAFLD in rats. Methods: Group I: Negative control rats received 2 ml of vehicle carboxy methyl cellulose (CMC). Group II: Rats received dexamethasone 8 mg/kg/day intraperitoneal for 6 days. Group III: Rats received oral stevia extract 400 mg/kg/day for 12 days. Group IV: Rats received dexamethasone + stevia extract. Serum ALT, AST, TC, TG and adiponectin were measured. MDA, GPx and TNF-α were estimated in liver homogenate. Histopathological changes and PPAR-α expressions in the liver were evaluated. Results: Dexamethasone caused a reduction in GPx and ADP levels with an elevation in ALT, AST, TC, TG, MDA and TNF-α. There was a decrease in immunostaining expression of liver PPAR-α. Stevia caused an improvement in liver enzymes, lipid profile, oxidative stress, TNF-α and adiponectin levels. Conclusion: Stevia provided some protection against dexamethasone-induced NAFLD. | ||||
Keywords | ||||
Dexamethasone; NAFLD; PPAR-α and Stevia | ||||
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