CELECOXIB NIOSOMAL IN-SITU GEL AS A VALUABLE DRUG DELIVERY SYSTEM FOR OCULAR INFLAMMATION
Ahmed, M., Khalil, I., Hassanein, K., El-Gendy, G., Ismail, S. (2023). CELECOXIB NIOSOMAL IN-SITU GEL AS A VALUABLE DRUG DELIVERY SYSTEM FOR OCULAR INFLAMMATION. EKB Journal Management System, 46(2), 757-783. doi: 10.21608/bfsa.2023.327673
Mohamed S. Ahmed; Ikramy A. Khalil; Khaled M. A. Hassanein; Gamal A. El-Gendy; Sayed Ismail. "CELECOXIB NIOSOMAL IN-SITU GEL AS A VALUABLE DRUG DELIVERY SYSTEM FOR OCULAR INFLAMMATION". EKB Journal Management System, 46, 2, 2023, 757-783. doi: 10.21608/bfsa.2023.327673
Ahmed, M., Khalil, I., Hassanein, K., El-Gendy, G., Ismail, S. (2023). 'CELECOXIB NIOSOMAL IN-SITU GEL AS A VALUABLE DRUG DELIVERY SYSTEM FOR OCULAR INFLAMMATION', EKB Journal Management System, 46(2), pp. 757-783. doi: 10.21608/bfsa.2023.327673
Ahmed, M., Khalil, I., Hassanein, K., El-Gendy, G., Ismail, S. CELECOXIB NIOSOMAL IN-SITU GEL AS A VALUABLE DRUG DELIVERY SYSTEM FOR OCULAR INFLAMMATION. EKB Journal Management System, 2023; 46(2): 757-783. doi: 10.21608/bfsa.2023.327673

CELECOXIB NIOSOMAL IN-SITU GEL AS A VALUABLE DRUG DELIVERY SYSTEM FOR OCULAR INFLAMMATION

Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 2, December 2023, Page 757-783  XML PDF (2.01 MB)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.327673
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Authors
Mohamed S. Ahmed1; Ikramy A. Khalil email 1; Khaled M. A. Hassanein2; Gamal A. El-Gendy1; Sayed Ismail1
1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
2Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, Egypt
Abstract
Niosomes are promising nanocarriers for ocular drug administration since they have
the potential to enhance the bioavailability and efficacy of different drugs. Meanwhile, topical gels are beneficial for the treatment of ocular inflammation as they improve corneal permeability and increase the contact time with the eye surface. The main purpose of this study was to prepare and evaluate novel niosomal gels for intraocular delivery of celecoxib. Different niosomes were prepared using different surfactants (span 60 and span 40) and cholesterol (30-50 mol %). The optimized formulation made with span 40 and cholesterol (7:3 molar ratio) has a relatively high encapsulation efficiency (~57%) with reasonable particle size for ocular delivery (~348 nm) and showed the highest release of ~65% after 24 hrs compared to other formulations. The optimized niosomal formulation was then used to prepare various formulations of celecoxib in-situ gel and topical hydrogels. The niosomal gels were well tolerated by the eye and showed similar celecoxib corneal permeation. However, the in-situ gel showed a higher anti-inflammatory effect compared to the topical hydrogel and a commercially available diclofenac eye drop. The results shown in this study indicate that celecoxib niosomal in-situ gel is a valuable drug delivery system for ocular inflammation.
Keywords
Celecoxib; niosomes; niosomal in-situ gel; niosomal hydrogel; in-vivo anti-inflammatory effect
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