Alloxan induces hyperglycemia, hyperlipidemia and immune disturbances in rats: potential protective effects of a brown algae powder | ||||
| مجلة کلية التربية النوعية - جامعة بورسعيد | ||||
| Article 8, Volume 21, Issue 21, July 2023 | ||||
| Document Type: المقالة الأصلية | ||||
| DOI: 10.21608/pssrj.2023.217319.1248 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
ايناس الهوارى  1; يوسف عبد العزيز الحسانين 2; عبير السيد حسن الخميسى3; نجلاء فتحي4
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| 1قسم الاقتصاد المنزلي - كلية التربية النوعية - جامعة بورسعيد | ||||
| 2کلية الاقتصاد المنزلى - جامعة المنوفية | ||||
| 3قسم الاقتصاد المنزلي - کلية التربية النوعية جامعة بورسعيد - بور سعيد - مصر | ||||
| 4قسم الاقتصاد المنزلى - كلية التربية النوعية - جامعة بورسعيد | ||||
| Abstract | ||||
| Abstract: Diabetes mellitus (DM) is a condition in which the regulation of homeostasis of carbohydrate and lipid metabolism by insulin is improper. This research paper was designed to explore how brown algae (Sargassum subrepandum) powder (BAP) affect DM and its complications (hyperlipidemia and immune disturbances) that alloxan induces in rats. Thirty-six rats were distributed to two groups: (Group 1, 6 rats) received basal diet (BD) and the other (30 rats) received alloxan then distributed to five subgroups: group (2) received BD as a model control, and the four remaining groups received BD with 2.5, 5.0, 7.5 and 10 % BAP. By completing the trial (4 weeks), treatment of rats with alloxan, model control group, induced a significant (p≤0.01) rise in the concentration of serum glucose by 165.38% compared with the control group. Dietary intervention with BAP (2.5, 5.0, 7.5 and 10%) in rats for twenty-eight days resulted in a significant (p≤0.05) decline in serum glucose levels, recording 155.71, 137.08, 108.64 and 91.14% compared with the control group. The decrease rate in serum glucose was presented as a dose-dependent increase with the levels of BAP intervention. Also, BAE was effective in protecting against DM complications including serum lipid profile (TG, TC, HDL-c, LDL-c and VLDL-c) and serum immunological parameters (Alb and TNF-α). Thus, the study recommends using the powder of this alga to 10% in food, beverages, as well as dietary supplements. | ||||
| Keywords | ||||
| Sargassum subrepandum; serum glucose; serum immunological parameters; serum lipid profile | ||||
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