Aromatase Inhibitors Versus Cabergoline for the Prevention of Ovarian Hyperstimulation Syndrome: a Prospective, Randomized, Double-Blind Study | ||||
| Evidence Based Women's Health Journal | ||||
| Article 4, Volume 7, Issue 1, February 2017, Page 22-29 PDF (890.02 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ebwhj.2017.3221 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Walid Attalla  ; Tarek Abd Elhamidb
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| Histopathology, Faculty of Medicine, Tanta University, Egypt, Department, Tanta University, Egypt | ||||
| Abstract | ||||
| Objective: To evaluate the effect of the aromatase inhibitor letrozole in the prevention of ovarian hyperstimulation syndrome (OHSS) in patients at risk during controlled ovarian hyperstimul (COH). Design: This is a prospective, randomized, double-blind study on women at risk of the development of OHSS during COH using gonadotropin-releasing hormone (GnRH) antagonist protocol Patients and Methods: This research was conducted at the Center of Assisted Reproduction, Om El-kora Hospital, Tanta, Egypt. Sixty patients, who were considered at risk of the development of OHSS during COH were enrolled in this study. Ovarian stimulation was performed using GnRH, whereas cabergoline (0.25 mg) given twice daily or letrozole (2.5 mg) twice daily from the day of oocyte retrieval for one week. Results: In the cabergoline group, two cases (6.6%) developed mild OHSS and one case (3.3%) developed moderate OHSS versus 8 (26.6%) mild OHSS and 6 (20%) moderate OHSS in the letrozole group. On the other hand, there was no statistically significant difference in the number of cases that developed severe OHSS in both groups where only one case (3.3%) developed severe OHSS in the cabergoline group vs. two (6.6%) cases in the letrozole group. Conclusion: Although letrozle administration during the luteal phase of ART cycles can reduce the high E2 level in hyper-responding patients, but it cannot prevent the development of early OHSS. On the contrary, Cabergoline can effectively prevent the development of early OHSS. | ||||
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