Clinical Characters of Egyptian children with Maturity Onset of Diabetes Type 3 | ||||
| Aswan University Medical Journal | ||||
| Volume 3, Issue 2, December 2023, Page 129-137 PDF (745.89 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aumj.2023.233837.1065 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Ahlam Mohamed Hafez 
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| Pediatrics department, Aswan university, Aswan, Egypt | ||||
| Abstract | ||||
| Abstract Background: Maturity-onset diabetes of the young (MODY) is a type of monogenic diabetes. MODY3 is more frequent than previously thought. Aim and objectives detect clinical characteristics of cases of MODY 3 as regarding age of disease onset, insulin dose, family history and complications in Egyptian children. Methods: This cross-sectional study was conducted on 20 cases and 10 controls. All subjects were subjected to full history taking, complete clinical examination and laboratory tests, including; C peptide assays, Glycosylated hemoglobin (HbA1c), Fasting and 2 hours postprandial blood sugar levels, Triglyceride, LDL cholesterol, Measurement of Anti-gad and anti-islets antibodies. Results: All cases (100%) had a positive family history of DM. All cases were negative for Anti-Gad and Anti-Islet. The mean age on onset of DM was 11.08 ± 2.77 years, the mean duration of DM was 2.2 ± 0.16 years. Regarding complications; 30% of cases has dental caries, 10% had neuropathy, 5% had hepatomegaly. Regarding treatment; 5% of cases were treated by oral hypoglycemic, 15 % were treated by insulin and oral hypoglycemic drugs, 15% were managed by healthy life style and 65% of cases treated by insulin with a mean dose 0.34 ± 0.19. Conclusion we suggest that a thorough clinical evaluation, including a family history, phenotypic features, a response to diabetes-specific autoantibodies, and an assessment of endogenous insulin secretion, may be a more effective first step in identifying diabetic children who require genetic testing for MODY. | ||||
| Keywords | ||||
| MODY3; Maturity Onset Diabetes of the young; Egyptian | ||||
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